U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TUM1 thiosulfate sulfurtransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854425, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    TUM1
    Gene description
    thiosulfate sulfurtransferase
    Primary source
    FungiDB:YOR251C
    Locus tag
    YOR251C
    See related
    SGD:S000005777; AllianceGenome:SGD:S000005777; VEuPathDB:YOR251C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables thiosulfate sulfurtransferase activity. Involved in tRNA wobble position uridine thiolation. Located in mitochondrion. Orthologous to human MPST (mercaptopyruvate sulfurtransferase) and TST (thiosulfate sulfurtransferase). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TUM1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (802550..803464, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 5 Neighboring gene cleavage polyadenylation factor subunit CLP1 Neighboring gene Tma16p Neighboring gene peptide alpha-N-acetyltransferase subunit NAT5

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of the Tum1 protein from the yeast Saccharomyces cerevisiae. Qiu R, et al. Protein Pept Lett, 2012 Nov. PMID 22587783
    2. Crystallization and preliminary X-ray analysis of the yeast tRNA-thiouridine modification protein 1 (Tum1p). Qiu R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Aug 1. PMID 21821903, Free PMC Article
    3. Tum1 is involved in the metabolism of sterol esters in Saccharomyces cerevisiae. Uršič K, et al. BMC Microbiol, 2017 Aug 22. PMID 28830344, Free PMC Article
    4. Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae. Pilkington LI , et al. Chem Commun (Camb), 2019 Jul 23. PMID 31240288
    5. Yeast genes involved in regulating cysteine uptake affect production of hydrogen sulfide from cysteine during fermentation. Huang CW, et al. FEMS Yeast Res, 2017 Aug 1. PMID 28810701

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the role of Tum1p in the production of hydrogen sulfide from cysteine
      Title: The yeast TUM1 affects production of hydrogen sulfide from cysteine treatment during fermentation.
    2. In this report, we describe the crystal structure of Tum1 protein at 1.90 A resolution which, despite consisting of two RLDs, has only one conserved cysteine residue in the C-terminal RLD.
      Title: Crystal structure of the Tum1 protein from the yeast Saccharomyces cerevisiae.
    3. crystals of Tum1p were obtained by the hanging-drop vapour-diffusion method and diffracted to 1.9 A resolution
      Title: Crystallization and preliminary X-ray analysis of the yeast tRNA-thiouridine modification protein 1 (Tum1p).
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-mercaptopyruvate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiosulfate sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiosulfate sulfurtransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA wobble position uridine thiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    thiosulfate sulfurtransferase
    NP_014894.3
    • Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; involved in metabolism of sterol esters; may be mitochondrially localized

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      802550..803464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183670.3 → NP_014894.3  TPA: thiosulfate sulfurtransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014894.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2V2, Q08686
      UniProtKB/TrEMBL
      A0A7I9C437, A6ZP89, C7GWD8, C8ZH03, G2WNB9, N1NVW9
      Conserved Domains (1) summary
      COG2897
      Location:1 → 302
      SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08686.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous