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    RRS1 Rrs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854469, updated on 4-Aug-2024

    Summary

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    Gene symbol
    RRS1
    Gene description
    Rrs1p
    Primary source
    FungiDB:YOR294W
    Locus tag
    YOR294W
    See related
    SGD:S000005820; AllianceGenome:SGD:S000005820; VEuPathDB:YOR294W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis; and ribosomal large subunit export from nucleus. Located in nuclear periphery; nucleolus; and nucleoplasm. Part of preribosome, large subunit precursor. Used to study Huntington's disease and thyroid gland papillary carcinoma. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RRS1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (868340..868951)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S10A Neighboring gene uncharacterized protein Neighboring gene Uaf30p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rrs1p, a ribosomal protein L11-binding protein, is required for nuclear export of the 60S pre-ribosomal subunit in Saccharomyces cerevisiae. Miyoshi K, et al. FEBS Lett, 2004 May 7. PMID 15135061
    2. Chaperoning 5S RNA assembly. Madru C, et al. Genes Dev, 2015 Jul 1. PMID 26159998, Free PMC Article
    3. Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in Saccharomyces cerevisiae. Horigome C, et al. Biosci Biotechnol Biochem, 2009 Feb. PMID 19202276
    4. Ebp2p, yeast homologue of a human protein that interacts with Epstein-Barr virus nuclear antigen 1, is required for pre-rRNA processing and ribosomal subunit assembly. Tsujii R, et al. Genes Cells, 2000 Jul. PMID 10947841
    5. RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Tsuno A, et al. Mol Cell Biol, 2000 Mar. PMID 10688653, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of Cgr1 results in inhibition of 5S ribonucleoprotein(RNP) rotation, but suppressor mutations mapping in factors Rpf2, Rrs1, and Rpl5, stabilizing the pre-rotational stage of the 5S RNP, partly overcome this defect.
      Title: Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.
    2. These results suggest that the ribosome biogenesis factors Ebp2 and Rrs1 cooperate with Mps3 to mediate telomere clustering, but not telomere tethering, by binding Sir4.
      Title: Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.
    3. identified a ribonucleoprotein neighborhood in preribosomes that contains two ribosome assembly factors, Rpf2 and Rrs1, two ribosomal proteins, rpL5 and rpL11, and 5S rRNA
      Title: Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes.
    4. Rrs1p has a role in coordinating the assembly of L5-5S rRNA on 60S ribosomal subunits.
      Title: Synergistic defect in 60S ribosomal subunit assembly caused by a mutation of Rrs1p, a ribosomal protein L11-binding protein, and 3'-extension of 5S rRNA in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rrs1p
    NP_014937.1
    • Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      868340..868951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183713.1 → NP_014937.1  TPA: Rrs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014937.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Z3, Q08746
      UniProtKB/TrEMBL
      A6ZPC9, B3LJV9, B5VSH2, C7GNW7, C8ZH44, G2WNG0, N1NWX7
      Conserved Domains (1) summary
      COG5225
      Location:9 → 203
      RRS1; Uncharacterized protein involved in ribosome biogenesis [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08746.1

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