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    TYE7 Tye7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854525, updated on 1-Aug-2024

    Summary

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    Gene symbol
    TYE7
    Gene description
    Tye7p
    Primary source
    FungiDB:YOR344C
    Locus tag
    YOR344C
    See related
    SGD:S000005871; AllianceGenome:SGD:S000005871; VEuPathDB:YOR344C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SGC1
    Summary
    Enables DNA-binding transcription factor activity. Involved in positive regulation of glycolytic process and transcription elongation from RNA polymerase II promoter. Located in chromatin. Human ortholog(s) of this gene implicated in cardiovascular system disease; disease of metabolism; and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1) and USF1 (upstream transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TYE7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (977194..978069, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Met Neighboring gene tRNA-Pro Neighboring gene deoxycytidyl transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. Gui W, et al. Acta Crystallogr F Struct Biol Commun, 2021 Oct 1. PMID 34605438, Free PMC Article
    2. Regulation of glycolysis by casein kinase I (Rag8p) in Kluyveromyces lactis involves a DNA-binding protein, Sck1p, a homologue of Sgc1p of Saccharomyces cerevisiae. Lemaire M, et al. Curr Genet, 2002 Mar. PMID 11919674
    3. The TYE7 gene of Saccharomyces cerevisiae encodes a putative bHLH-LZ transcription factor required for Ty1-mediated gene expression. Löhning C, et al. Yeast, 1994 Oct. PMID 7900422
    4. The GCR1 requirement for yeast glycolytic gene expression is suppressed by dominant mutations in the SGC1 gene, which encodes a novel basic-helix-loop-helix protein. Nishi K, et al. Mol Cell Biol, 1995 May. PMID 7739544, Free PMC Article
    5. Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape. Gordân R, et al. Cell Rep, 2013 Apr 25. PMID 23562153, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ty1 activation in response to adenylic nucleotide depletion requires the DNA-binding transcription factor Tye7.
      Title: Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress.
    2. Tye7 is a metabolic targets of Skp1-Cul1-F-box (SCF) ubiquitin ligase.
      Title: A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of glycolytic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tye7p
    NP_014989.3
    • Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; bHLH stands for basic-helix-loop-helix

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      977194..978069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183764.3 → NP_014989.3  TPA: Tye7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014989.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W340, P33122
      UniProtKB/TrEMBL
      A6ZPH5, B3LK02, C7GNS3, G2WNK5, N1NX18
      Conserved Domains (1) summary
      cd11395
      Location:179 → 283
      bHLHzip_SREBP_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33122.1

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