RLM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RLM1
Primary source: SGD:S000006010
Locus tag: YPL089C
See related: AllianceGenome:SGD:S000006010; FungiDB:YPL089C; VEuPathDB:YPL089C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA binding activity, bending; DNA-binding transcription factor activity, RNA polymerase II-specific; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription from RNA polymerase II promoter in response to stress; regulation of G1 to G0 transition; and regulation of flocculation. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 20 and dilated cardiomyopathy. Orthologous to several human genes including MEF2A (myocyte enhancer factor 2A); MEF2C (myocyte enhancer factor 2C); and MEF2D (myocyte enhancer factor 2D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (379120..381150, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.
Title: An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.
We describe here a role for the yeast MAPK Slt2 as a part of the transcriptional activation machinery necessary for the regulation of Rlm1-dependent genes.
Title: Slt2 MAPK association with chromatin is required for transcriptional activation of Rlm1 dependent genes upon cell wall stress.
Rlm1 regulates the transition from G1 to S. rlm1Delta mutant forms cell groups in which a mother cell is surrounded by smaller "satellite-daughter" cells. rlm1Delta satellite daughters were unable to grow or divide further.
Title: Shrinking Daughters: Rlm1-Dependent G(1)/S Checkpoint Maintains Saccharomyces cerevisiae Daughter Cell Size and Viability.
this paper shows that, under cell wall stress conditions, Rlm1 interacts with Rlm1-binding domains at the promoter regions of RLM1 and SLT2, eliciting transcriptional positive-feedback mechanisms
Title: Rlm1 mediates positive autoregulatory transcriptional feedback that is essential for Slt2-dependent gene expression.
Mutation of certain phosphorylation sites in RLM1 inhibits the induction of RCK1 expression by Kdx1
Title: Kdx1 regulates RCK1 gene expression by interacting with Rlm1 in Saccharomyces cerevisiae.
RLM1 deletion decreases the transcription of SLT2 encoding the Mpk1p kinase.
Title: Comparative transcriptome analysis of yeast strains carrying slt2, rlm1, and pop2 deletions.
during cell wall stress, the interaction of Slt2p with Cdc37p and Hsp90 is crucial for Slt2p-dependent downstream responses, such as the activation of the transcription factor Rlm1p
Title: Cdc37p is required for stress-induced high-osmolarity glycerol and protein kinase C mitogen-activated protein kinase pathway functionality by interaction with Hog1p and Slt2p (Mpk1p).

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G1 to G0 transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of flocculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rlm1p

NP_015236.1

MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

379120..381150 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183903.1 → NP_015236.1 TPA: Rlm1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015236.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3S8, Q12224

UniProtKB/TrEMBL

G2WP92, N1NVX2

Conserved Domains (2) summary

COG5068
Location:146 → 673

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 77

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...