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    COX11 Cox11p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855971, updated on 1-Aug-2024

    Summary

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    Gene symbol
    COX11
    Gene description
    Cox11p
    Primary source
    FungiDB:YPL132W
    Locus tag
    YPL132W
    See related
    SGD:S000006053; AllianceGenome:SGD:S000006053; VEuPathDB:YPL132W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPI13; PSO7
    Summary
    Enables copper ion binding activity. Involved in aerobic respiration and cellular protein-containing complex assembly. Located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial ribosome. Orthologous to human COX11 (cytochrome c oxidase copper chaperone COX11). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COX11 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (301716..302618)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mitochondrial 2-oxodicarboxylate carrier Neighboring gene gluconeogenesis transcription factor RDS2 Neighboring gene ribosomal 60S subunit protein L5 Neighboring gene Spo19p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancestral and derived protein import pathways in the mitochondrion of Reclinomonas americana. Tong J, et al. Mol Biol Evol, 2011 May. PMID 21081480, Free PMC Article
    2. Mutational analysis of the Saccharomyces cerevisiae cytochrome c oxidase assembly protein Cox11p. Banting GS, et al. Eukaryot Cell, 2006 Mar. PMID 16524911, Free PMC Article
    3. Functional analysis of the domains in Cox11. Carr HS, et al. J Biol Chem, 2005 Jun 17. PMID 15840584
    4. Mutant allele pso7-1, that sensitizes Saccharomyces cerevisiae to photoactivated psoralen, is allelic with COX11, encoding a protein indispensable for a functional cytochrome c oxidase. Pungartnik C, et al. Curr Genet, 1999 Sep. PMID 10501934
    5. A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase. Swaminathan AB, et al. Genetics, 2022 Jul 30. PMID 35666203, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel COX11 Mutations Associated with Mitochondrial Disorder: Functional Characterization in Patient Fibroblasts and Saccharomyces cerevisiae.
      Title: Novel COX11 Mutations Associated with Mitochondrial Disorder: Functional Characterization in Patient Fibroblasts and Saccharomyces cerevisiae.
    2. The mitochondrial copper chaperone COX11 has an additional role in cellular redox homeostasis.
      Title: The mitochondrial copper chaperone COX11 has an additional role in cellular redox homeostasis.
    3. Data show that hydrogen peroxide sensitivity of sco1Delta and cox11Delta cells is abrogated by overexpression of a novel mitochondrial ATPase Afg1 that promotes the degradation of CcO mitochondrially encoded subunits.
      Title: Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase.
    4. COX11 is an integral protein of the inner mitochondrial membrane that is essential for cytochrome c oxidase assembly.
      Title: Mutational analysis of the Saccharomyces cerevisiae cytochrome c oxidase assembly protein Cox11p.
    5. THe copper binding site is co-translationally formed by a transient interaction between Cox11 and the nascent cytochrome C oxidase in the intermembrane space.
      Title: Evidence for the association of yeast mitochondrial ribosomes with Cox11p, a protein required for the Cu(B) site formation of cytochrome c oxidase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cox11p
    NP_015193.1
    • Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; involved in oxidative stress response; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      301716..302618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183946.1 → NP_015193.1  TPA: Cox11p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015193.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3N5, P19516
      UniProtKB/TrEMBL
      A6ZWC0, B3LKU3, B5VT33, C7GJ85, C8ZIP8, G2WP49, N1NVG3
      Conserved Domains (1) summary
      COG3175
      Location:76 → 269
      COX11; Cytochrome c oxidase assembly protein Cox11 [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19516.2

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