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    RPL7B ribosomal 60S subunit protein L7B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855903, updated on 4-Aug-2024

    Summary

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    Gene symbol
    RPL7B
    Gene description
    ribosomal 60S subunit protein L7B
    Primary source
    FungiDB:YPL198W
    Locus tag
    YPL198W
    See related
    SGD:S000006119; AllianceGenome:SGD:S000006119; VEuPathDB:YPL198W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in maturation of LSU-rRNA. Located in cytoplasm and nucleolus. Part of cytosolic large ribosomal subunit. Orthologous to several human genes including RPL7 (ribosomal protein L7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPL7B in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    3
    Sequence:
    Chromosome: XVI; NC_001148.4 (173152..174702)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Csm4p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Oxr1p Neighboring gene Apl5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human ribosomal protein L7 carries two nucleic acid-binding domains with distinct specificities. von Mikecz A, et al. Biochem Biophys Res Commun, 1999 May 19. PMID 10329420
    2. The evolutionary relationships between homologs of ribosomal YL8 protein and YL8-like proteins. Mizuta K, et al. Curr Genet, 1995 Jun. PMID 8536309
    3. Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae. Palumbo RJ, et al. G3 (Bethesda), 2017 Feb 9. PMID 28007835, Free PMC Article
    4. Association of ribosomal proteins with nascent transcripts in S. cerevisiae. Schroder PA, et al. RNA, 2005 Oct. PMID 16199762, Free PMC Article
    5. Differential subcellular localization of ribosomal protein L7 paralogs in Saccharomyces cerevisiae. Kim TY, et al. Mol Cells, 2009 May 31. PMID 19466602

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Among mutants harboring a single native or chimeric RPL7 allele, expression from the RPL7A locus exceeded that from the RPL7B locus, and more Rpl7a was expressed from either locus than Rpl7b Phenotypic differences in tunicamycin sensitivity
      Title: Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae.
    2. L7 and L8 might establish RNP structures within assembling ribosomes necessary for the stable association and function of the A(3) assembly factors and for proper assembly of the neighborhoods containing domains I and II.
      Title: Ribosomal proteins L7 and L8 function in concert with six A₃ assembly factors to propagate assembly of domains I and II of 25S rRNA in yeast 60S ribosomal subunits.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L7B
    NP_015126.1
    • Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      173152..174702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184012.1 → NP_015126.1  TPA: ribosomal 60S subunit protein L7B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015126.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3H1, Q12213
      UniProtKB/TrEMBL
      A6ZW56, B3LKN1, C8ZII1, G2WNY6
      Conserved Domains (1) summary
      TIGR01310
      Location:10 → 244
      uL30_euk; 60S ribosomal protein uL30, eukaryotic form
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12213.3

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