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    CIP1 Cip1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856093, updated on 17-May-2024

    Summary

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    Gene symbol
    CIP1
    Gene description
    Cip1p
    Primary source
    FungiDB:YPL014W
    Locus tag
    YPL014W
    See related
    SGD:S000005935; AllianceGenome:SGD:S000005935; VEuPathDB:YPL014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CIP1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (527547..528692)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Swi1p Neighboring gene histone deacetylase HST2 Neighboring gene mitochondrial 37S ribosomal protein MRPS16 Neighboring gene mRNA-binding protein RRP12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cip1 tunes cell cycle arrest duration upon calcineurin activation. Flynn MJ, et al. Proc Natl Acad Sci U S A, 2022 Jun 7. PMID 35653562, Free PMC Article
    2. Cdk1-interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stress. Zhang Z, et al. Genes Cells, 2017 Oct. PMID 28771906, Free PMC Article
    3. Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae. Ren P, et al. Genes Cells, 2016 Jun. PMID 27005485
    4. Dual Repressive Function by Cip1, a Budding Yeast Analog of p21, in Cell-Cycle START Regulation. Li P, et al. Front Microbiol, 2020. PMID 32733430, Free PMC Article
    5. Yeast Cip1 is activated by environmental stress to inhibit Cdk1-G1 cyclins via Mcm1 and Msn2/4. Chang YL, et al. Nat Commun, 2017 Jul 4. PMID 28676626, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cip1 tunes cell cycle arrest duration upon calcineurin activation.
      Title: Cip1 tunes cell cycle arrest duration upon calcineurin activation.
    2. Cip1 accumulates dramatically in a Mec1- and Rad53-dependent manner upon replication stress. Cip1 is phosphorylated at an S/TQ consensus motif in a Mec1-dependent manner. Deletion of Cip1 affects proliferation in hydroxyurea-containing plates.
      Title: Cdk1-interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stress.
    3. functions similarly to mammalian p21 as a stress-induced CDK inhibitor to decelerate cell cycle through G1 cyclins to cope with environmental stresses; regulated by cycle (Mcm1) and stress-mediated (Msn 2/4) transcription factors
      Title: Yeast Cip1 is activated by environmental stress to inhibit Cdk1-G1 cyclins via Mcm1 and Msn2/4.
    4. Study reports a novel Cdk1-interacting protein, YPL014W, named Cip1 (for Cdk1-interacting protein 1); results show that Cip1 specifically interacts with G1 /S-phase Cln2-Cdk1 complex but not with S-phase Clb5-Cdk1 or M-phase Clb2-Cdk1 complexes.
      Title: Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cip1p
    NP_015311.1
    • Cyclin-dependent kinase inhibitor; activated by environmental stress; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; overexpression blocks cells in G1 phase and stabilizes the Cdc28p inhibitor Sic1p, while disruption accelerates the G1/S phase transition; phosphorylated during S phase in a Cdc28p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      527547..528692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183828.1 → NP_015311.1  TPA: Cip1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015311.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Z8, Q02606
      UniProtKB/TrEMBL
      A0A6A5Q5K9, A6ZWN2, B3LL48, C7GU36, C8ZJ14, N1NVI7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02606.1

    Gene LinkOut

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