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    CWC27 putative peptidylprolyl isomerase CWC27 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856041, updated on 1-Aug-2024

    Summary

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    Gene symbol
    CWC27
    Gene description
    putative peptidylprolyl isomerase CWC27
    Primary source
    FungiDB:YPL064C
    Locus tag
    YPL064C
    See related
    SGD:S000005985; AllianceGenome:SGD:S000005985; VEuPathDB:YPL064C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Part of U2-type spliceosomal complex. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CWC27 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (428711..429616, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rgl1p Neighboring gene ESCRT-I subunit protein VPS28 Neighboring gene protein translocase subunit TIM50 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome. Wlodaver AM, et al. RNA, 2014 Mar. PMID 24442613, Free PMC Article
    2. Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. van Nues RW, et al. Genetics, 2001 Apr. PMID 11290703, Free PMC Article
    3. Structure of a yeast activated spliceosome at 3.5 Å resolution. Yan C, et al. Science, 2016 Aug 26. PMID 27445306
    4. Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase. Cordin O, et al. Nucleic Acids Res, 2014 Dec 16. PMID 25428373, Free PMC Article
    5. Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing. Lardelli RM, et al. RNA, 2010 Mar. PMID 20089683, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative peptidylprolyl isomerase CWC27
    NP_015261.1
    • Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      428711..429616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183878.1 → NP_015261.1  TPA: putative peptidylprolyl isomerase CWC27 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015261.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3V1, Q02770
      UniProtKB/TrEMBL
      G2WPB6, N1P1Q2
      Conserved Domains (1) summary
      cl00197
      Location:6 → 167
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02770.1

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