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    GDH2 glutamate dehydrogenase (NAD(+)) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851311, updated on 29-Jun-2024

    Summary

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    Gene symbol
    GDH2
    Gene description
    glutamate dehydrogenase (NAD(+))
    Primary source
    FungiDB:YDL215C
    Locus tag
    YDL215C
    See related
    SGD:S000002374; AllianceGenome:SGD:S000002374; VEuPathDB:YDL215C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutamate dehydrogenase (NAD+) activity. Involved in nitrogen compound metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GDH2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (70640..73918, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene translocation channel protein TIM22 Neighboring gene COP9 signalosome catalytic subunit RRI1 Neighboring gene serine/threonine protein kinase PRR2 Neighboring gene Nop6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tor1/2 regulation of retrograde gene expression in Saccharomyces cerevisiae derives indirectly as a consequence of alterations in ammonia metabolism. Tate JJ, et al. J Biol Chem, 2003 Sep 19. PMID 12851403, Free PMC Article
    2. Phosphorylation and proteolysis regulate the NAD-dependent glutamate dehydrogenase from Saccharomyces cerevisiae. Hemmings BA. FEBS Lett, 1980 Dec 29. PMID 7009211
    3. Simultaneous isolation of the yeast cytosol and well-preserved mitochondria with negligible contamination by vacuolar proteinases. Schwencke J, et al. FEBS Lett, 1983 Jun 13. PMID 6343120
    4. Regulation of NAD-dependent glutamate dehydrogenase by protein kinases in Saccharomyces cerevisiae. Uno I, et al. J Biol Chem, 1984 Jan 25. PMID 6319381
    5. Effect of glucose, galactose, and different nitrogen-sources on the activity of yeast glutamate dehydrogenase (NAD and NADP-linked) from normal strain and impaired respiration mutant. Nuñez de Castro I, et al. Eur J Biochem, 1970 Nov. PMID 4394512

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glutamate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate catabolic process to 2-oxoglutarate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate dehydrogenase (NAD(+))
    NP_010066.1
    • NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      70640..73918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180275.1 → NP_010066.1  TPA: glutamate dehydrogenase (NAD(+)) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010066.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRD9, P33327
      UniProtKB/TrEMBL
      A0A8H8UM86, G2WBV2, N1P679
      Conserved Domains (1) summary
      cl29306
      Location:1 → 1092
      Bac_GDH; Bacterial NAD-glutamate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33327.1

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