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    TMN3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856849, updated on 11-Sep-2024

    Summary

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    Official Symbol
    TMN3
    Primary source
    SGD:S000000915
    Locus tag
    YER113C
    See related
    AllianceGenome:SGD:S000000915; FungiDB:YER113C; VEuPathDB:YER113C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including cellular copper ion homeostasis; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in Golgi apparatus. Colocalizes with COPI-coated vesicle. Orthologous to human TM9SF4 (transmembrane 9 superfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (387932..390052, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene SBF complex DNA-binding subunit SWI4 Neighboring gene U6 snRNA complex subunit LSM4 Neighboring gene Boi2p Neighboring gene Spr6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transmembrane nine proteins in yeast and Arabidopsis affect cellular metal contents without changing vacuolar morphology. Hegelund JN, et al. Physiol Plant, 2010 Dec. PMID 20681974
    2. Characterization of a 76 kDa endosomal, multispanning membrane protein that is highly conserved throughout evolution. Schimmöller F, et al. Gene, 1998 Aug 31. PMID 9729438
    3. Control of cellular physiology by TM9 proteins in yeast and Dictyostelium. Froquet R, et al. J Biol Chem, 2008 Mar 14. PMID 18178563
    4. Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast. Dardalhon M, et al. FEMS Yeast Res, 2007 Sep. PMID 17608707, Free PMC Article
    5. The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2. Schillewaert S, et al. Mol Cell Biol, 2012 Jan. PMID 22083961, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular copper ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuolar transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tmn3p
    NP_011038.3
    • Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      387932..390052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179003.3 → NP_011038.3  TPA: Tmn3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011038.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM19, P40071
      UniProtKB/TrEMBL
      B3LRM9, C8Z7D1
      Conserved Domains (1) summary
      pfam02990
      Location:78 → 663
      EMP70; Endomembrane protein 70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40071.1

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