SUC2 beta-fructofuranosidase SUC2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SUC2
Gene description: beta-fructofuranosidase SUC2
Primary source: FungiDB:YIL162W
Locus tag: YIL162W
See related: SGD:S000001424; AllianceGenome:SGD:S000001424; VEuPathDB:YIL162W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables beta-fructofuranosidase activity and inulinase activity. Involved in inulin catabolic process; raffinose catabolic process; and sucrose catabolic process. Located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SUC2 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (37385..38983)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inulin catabolism in Saccharomyces cerevisiae is affected by some key glycosylation sequons of invertase Suc2.
Title: Inulin catabolism in Saccharomyces cerevisiae is affected by some key glycosylation sequons of invertase Suc2.
Pro152 and Lys153 play a key role in preparation of the right substrate lodging in the active site of SUC2 invertase.
Title: Catalytic efficiency and thermostability improvement of Suc2 invertase through rational site-directed mutagenesis.
Data indicate that Rgt1 and tpk1/2/3 (cAMP-dependent protein kinases) participate in the control of SUC2 expression.
Title: The repressor Rgt1 and the cAMP-dependent protein kinases control the expression of the SUC2 gene in Saccharomyces cerevisiae.
In S. cerevisiae glucose and sucrose were inulinase inducer and repressor, respectively.
Title: [Expression of inulinase genes in the yeasts Saccharomyces cerevisiae and Kluyveromyces marxianus].
It was shown that the target suc2 gene is actively expressed in the genome of the transformed potato plants and S. cerevisiae invertase synthesized by this gene is transported into the apoplast due to the signal peptide of the proteinase II inhibitor.
Title: [Characteristics of extracellular invertase of Saccharomyces cerevisiae in Heterologous expression of the suc2 gene in Solarium Tuberosum plants].
the crystal structure of recombinant SInv at 3.3 A resolution shows that the enzyme folds into the catalytic beta-propeller and beta-sandwich domains characteristic of GH32 enzymes
Title: Three-dimensional structure of Saccharomyces invertase: role of a non-catalytic domain in oligomerization and substrate specificity.
Crystallization and preliminary X-ray diffraction analysis of the invertase from Saccharomyces cerevisiae
Title: Crystallization and preliminary X-ray diffraction analysis of the invertase from Saccharomyces cerevisiae.
Mutagenesis studies confirmed the implication of Asn 228 in directing the orientation of the sucrose molecule for the specific synthesis of beta(2,6) linkages.
Title: Fructo-oligosaccharide synthesis by mutant versions of Saccharomyces cerevisiae invertase.
Comparative genetics of yeast Saccharomyces cerevisiae: chromosomal translocations carrying the SUC2 marker
Title: [Comparative genetics of yeast Saccharomyces cerevisiae: chromosomal translocations carrying the SUC2 marker].
Snf7 influences SUC2 gene expression through activation of the Rim101 pathway.
Title: ESCRT-III protein Snf7 mediates high-level expression of the SUC2 gene via the Rim101 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables beta-fructofuranosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-fructofuranosidase activity	IEA Inferred from Electronic Annotation more info
enables beta-fructofuranosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables inulinase activity	IDA Inferred from Direct Assay more info	PubMed
enables sucrose alpha-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructan catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inulin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in raffinose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sucrose catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sucrose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sucrose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: beta-fructofuranosidase SUC2

NP_012104.1

EC 3.2.1.26

Invertase; sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

37385..38983

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179510.1 → NP_012104.1 TPA: beta-fructofuranosidase SUC2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012104.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVC4, P00724, Q12671

UniProtKB/TrEMBL

D5MS20, D5MS22, G2WFY9, N1P2F8

Conserved Domains (1) summary

COG1621
Location:12 → 530

SacC; Sucrose-6-phosphate hydrolase SacC, GH32 family [Carbohydrate transport and metabolism]