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    UBP9 putative ubiquitin-specific protease UBP9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856835, updated on 1-Aug-2024

    Summary

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    Gene symbol
    UBP9
    Gene description
    putative ubiquitin-specific protease UBP9
    Primary source
    FungiDB:YER098W
    Locus tag
    YER098W
    See related
    SGD:S000000900; AllianceGenome:SGD:S000000900; VEuPathDB:YER098W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Located in cytoplasm. Orthologous to human USP12 (ubiquitin specific peptidase 12) and USP46 (ubiquitin specific peptidase 46). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UBP9 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (355466..357730)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Shc1p Neighboring gene tRNA-Glu Neighboring gene ribose phosphate diphosphokinase subunit PRS2 Neighboring gene E2 ubiquitin-conjugating protein UBC6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. Kanga S, et al. PLoS One, 2012. PMID 22723847, Free PMC Article
    2. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Hu B, et al. Mol Microbiol, 2005 Mar. PMID 15752197
    3. Ubiquitin-dependent protein degradation. Hochstrasser M. Annu Rev Genet, 1996. PMID 8982460
    4. Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress. Kandel R, et al. PLoS Biol, 2023 Jan. PMID 36689475, Free PMC Article
    5. Dissection of USP catalytic domains reveals five common insertion points. Ye Y, et al. Mol Biosyst, 2009 Dec. PMID 19734957

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative ubiquitin-specific protease UBP9
    NP_011024.1
    • Putative ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      355466..357730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178989.1 → NP_011024.1  TPA: putative ubiquitin-specific protease UBP9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011024.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM05, P39967
      UniProtKB/TrEMBL
      B3LRL6, C8Z7B6
      Conserved Domains (1) summary
      cl02553
      Location:390 → 665
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39967.1

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