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    MNL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850746, updated on 11-Sep-2024

    Summary

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    Official Symbol
    MNL2
    Primary source
    SGD:S000004047
    Locus tag
    YLR057W
    See related
    AllianceGenome:SGD:S000004047; FungiDB:YLR057W; VEuPathDB:YLR057W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1); MAN1A2 (mannosidase alpha class 1A member 2); and MAN1C1 (mannosidase alpha class 1C member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (255306..257855)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene SAGA complex subunit SPT8 Neighboring gene C-5 sterol desaturase Neighboring gene glycine hydroxymethyltransferase SHM2 Neighboring gene Rex2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic analysis of α1,2-mannosidase-like protein deletion mutants in Saccharomyces cerevisiae. Nakamasu S, et al. MicroPubl Biol, 2022. PMID 36217443, Free PMC Article
    2. Mnl2, a novel component of the ER associated protein degradation pathway. Martinez Benitez E, et al. Biochem Biophys Res Commun, 2011 Oct 28. PMID 21971548
    3. Combining multisource information through functional-annotation-based weighting: gene function prediction in yeast. Ray SS, et al. IEEE Trans Biomed Eng, 2009 Feb. PMID 19272921
    4. Endoplasmic reticulum-associated degradation (ERAD) and free oligosaccharide generation in Saccharomyces cerevisiae. Chantret I, et al. J Biol Chem, 2011 Dec 2. PMID 21979948, Free PMC Article
    5. Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae. Morimoto Y, et al. Mol Microbiol, 2015 Feb. PMID 25471153

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose trimming involved in glycoprotein ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative mannosidase MNL2
    NP_013158.1
    • Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      255306..257855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181944.1 → NP_013158.1  TPA: putative mannosidase MNL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013158.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY59, Q12205, Q7LGY1
      UniProtKB/TrEMBL
      G2WIQ0, N1NZ44
      Conserved Domains (1) summary
      cl04955
      Location:197 → 848
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12205.1

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