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    SCD5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854507, updated on 11-Sep-2024

    Summary

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    Official Symbol
    SCD5
    Primary source
    SGD:S000005856
    Locus tag
    YOR329C
    See related
    AllianceGenome:SGD:S000005856; FungiDB:YOR329C; VEuPathDB:YOR329C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FTB1; SCD7
    Summary
    Enables protein phosphatase 1 binding activity. Involved in cortical actin cytoskeleton organization; positive regulation of clathrin-dependent endocytosis; and protein secretion. Located in actin cortical patch and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (936731..939349, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene SNAP receptor SNC2 Neighboring gene ATP-binding cassette multidrug transporter PDR10 Neighboring gene DNA-directed DNA polymerase gamma MIP1 Neighboring gene H(+)-transporting V1 sector ATPase subunit E

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cortical recruitment and nuclear-cytoplasmic shuttling of Scd5p, a protein phosphatase-1-targeting protein involved in actin organization and endocytosis. Chang JS, et al. Mol Biol Cell, 2006 Jan. PMID 16251346, Free PMC Article
    2. Identification of novel recognition motifs and regulatory targets for the yeast actin-regulating kinase Prk1p. Huang B, et al. Mol Biol Cell, 2003 Dec. PMID 13679512, Free PMC Article
    3. Protein phosphatase-1 binding to scd5p is important for regulation of actin organization and endocytosis in yeast. Chang JS, et al. J Biol Chem, 2002 Dec 13. PMID 12356757
    4. SCD5, a suppressor of clathrin deficiency, encodes a novel protein with a late secretory function in yeast. Nelson KK, et al. Mol Biol Cell, 1996 Feb. PMID 8688556, Free PMC Article
    5. The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis. Henry KR, et al. Curr Biol, 2003 Sep 2. PMID 12956961

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Scd5/PP1 is important for recycling Prk1 targets to initiate new rounds of endocytosis and provide new mechanistic information on the role of the Sla1 SR domain in regulating progression to the invagination/actin phase of endocytosis.
      Title: Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis.
    2. Glc7p antagonizes the activity of the Prk1p kinase in regulating the functions of Pan1p and possibly other actin- and endocytosis-related proteins
      Title: Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeast.
    3. nuclear-cytoplasmic shuttling is not required for regulation of Scd5p's cortical function and suggest that Scd5p has an independent nuclear function
      Title: Cortical recruitment and nuclear-cytoplasmic shuttling of Scd5p, a protein phosphatase-1-targeting protein involved in actin organization and endocytosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of clathrin-dependent endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Scd5p
    NP_014974.3
    • Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      936731..939349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183749.3 → NP_014974.3  TPA: Scd5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014974.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W326, P34758
      UniProtKB/TrEMBL
      A6ZPG1, B3LJZ0, C7GNT5, C8ZH80, G2WNJ3, N1NW82
      Conserved Domains (1) summary
      pfam05109
      Location:433 → 658
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34758.1

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