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    mafa MAF bZIP transcription factor a [ Danio rerio (zebrafish) ]

    Gene ID: 114467, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mafaprovided by ZNC
    Official Full Name
    MAF bZIP transcription factor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010605-2
    See related
    Ensembl:ENSDARG00000015890 AllianceGenome:ZFIN:ZDB-GENE-010605-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    maf; c-Maf; Z-cmaf; fl13d12; wu:fl13d12
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; pronephric mesoderm; pronephric proximal convoluted tubule; pronephric proximal straight tubule; and solid lens vesicle. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mafa in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (29402611..29589340)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (29423918..29435605)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488292 Neighboring gene uncharacterized LOC137488293 Neighboring gene PPFIA binding protein 2a Neighboring gene uncharacterized LOC137488233 Neighboring gene C-x(9)-C motif containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR. Leask M, et al. Front Genet, 2018. PMID 30719032, Free PMC Article
    2. Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter. Kajihara M, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680841
    3. Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals. Kim JW, et al. Dev Cell, 2016 Jun 20. PMID 27326930, Free PMC Article
    4. Phylogenomic analysis and expression patterns of large Maf genes in Xenopus tropicalis provide new insights into the functional evolution of the gene family in osteichthyans. Coolen M, et al. Dev Genes Evol, 2005 Jul. PMID 15759153
    5. β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs. Ibrahim S, et al. Mol Metab, 2021 Nov. PMID 34246804, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Maf
    Names
    proto-oncogene c-maf
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
    v-maf musculoaponeurotic fibrosarcoma oncogene homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131844.2 → NP_571919.2  transcription factor Maf

      Status: VALIDATED

      Source sequence(s)
      BC065941, EH583521
      UniProtKB/TrEMBL
      A0A8M1PD50, Q6NZW9
      Related
      ENSDARP00000108952.2, ENSDART00000014703.7
      Conserved Domains (2) summary
      cd14718
      Location:234 → 302
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:86 → 119
      Maf_N; Maf N-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      29402611..29589340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467572.2 → XP_021323247.1  transcription factor Maf isoform X1

      UniProtKB/TrEMBL
      A0A286Y8Q5, A0A8M9P0X6
      Related
      ENSDARP00000143556.1, ENSDART00000176966.2
      Conserved Domains (2) summary
      cd14718
      Location:234 → 302
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:86 → 119
      Maf_N; Maf N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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