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    brd2a bromodomain containing 2a [ Danio rerio (zebrafish) ]

    Gene ID: 30445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brd2aprovided by ZNC
    Official Full Name
    bromodomain containing 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-248
    See related
    Ensembl:ENSDARG00000022280 AllianceGenome:ZFIN:ZDB-GENE-990415-248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    brd2; ring3; fe47f02; fi85h05; wu:fe47f02; wu:fi85h05
    Summary
    Predicted to enable lysine-acetylated histone binding activity. Acts upstream of or within central nervous system development; regulation of apoptotic process; and thrombocyte differentiation. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See brd2a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7152955..7170675)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7235576..7251749)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 9a Neighboring gene transporter associated with antigen processing, subunit type a Neighboring gene hydroxysteroid (17-beta) dehydrogenase 8 Neighboring gene collagen, type XI, alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence. Dibenedetto AJ, et al. BMC Dev Biol, 2008 Apr 10. PMID 18402692, Free PMC Article
    2. Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development. Reisser M, et al. Nat Commun, 2018 Dec 6. PMID 30523256, Free PMC Article
    3. Knockdown of epigenetic transcriptional co-regulator Brd2a disrupts apoptosis and proper formation of hindbrain and midbrain-hindbrain boundary (MHB) region in zebrafish. Murphy T, et al. Mech Dev, 2017 Aug. PMID 28549975
    4. Evolutionary history of the ABCB2 genomic region in teleosts. Palti Y, et al. Dev Comp Immunol, 2007. PMID 17055577
    5. Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration. Ko S, et al. J Hepatol, 2016 Feb. PMID 26505118, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results suggest an evolutionarily conserved role for Brd2 in the proper formation and/or patterning of segmented tissues, including the vertebrate CNS, where it acts as a bi-modal regulator of apoptosis, and is necessary, directly or indirectly, for proper expression of genes that pattern the MHB and/or regulate differentiation in the anterior hindbrain.
      Title: Knockdown of epigenetic transcriptional co-regulator Brd2a disrupts apoptosis and proper formation of hindbrain and midbrain-hindbrain boundary (MHB) region in zebrafish.
    2. brd2a on chromosome 19 exhibits both maternal and zygotic contributions to early development and patterning, analogous to the brd2 ortholog in Drosophila.
      Title: Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence.
    3. Expression profiles of zebrafish brd2 paralogs support a role in vertebrate developmental patterning and morphogenesis
      Title: Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within midbrain-hindbrain boundary development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spinal cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thrombocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 2a
    Names
    bromodomain-containing 2
    ring finger protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270571.1 → NP_001257500.1  bromodomain-containing protein 2a isoform 2

      See identical proteins and their annotated locations for NP_001257500.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N-and C-termini compared to isoform 1.
      Source sequence(s)
      BC163902, EB772248, FP085392
      UniProtKB/TrEMBL
      B3DKM5, Q1LWX7
      Related
      ENSDARP00000139243.1, ENSDART00000160894.2
      Conserved Domains (3) summary
      cd05497
      Location:72 → 178
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:383 → 484
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:672 → 734
      BET; Bromodomain extra-terminal - transcription regulation

    2. NM_131200.2 → NP_571275.2  bromodomain-containing protein 2a isoform 1

      See identical proteins and their annotated locations for NP_571275.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC163902, EB772248, FP085392
      UniProtKB/TrEMBL
      A0A8N1TTX0, A8CYR1
      Related
      ENSDARP00000038787.6, ENSDART00000035967.8
      Conserved Domains (3) summary
      cd05497
      Location:72 → 178
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:383 → 484
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:676 → 738
      BET; Bromodomain extra-terminal - transcription regulation

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      7152955..7170675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215022.1 → XP_068071123.1  bromodomain-containing protein 2a isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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