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    tdrd7a tudor domain containing 7 a [ Danio rerio (zebrafish) ]

    Gene ID: 406379, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tdrd7aprovided by ZNC
    Official Full Name
    tudor domain containing 7 aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2103
    See related
    Ensembl:ENSDARG00000032808 AllianceGenome:ZFIN:ZDB-GENE-040426-2103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tdrd7; zgc:56669; wu:fi12c12; si:ch211-288h2.2
    Summary
    Predicted to enable mRNA binding activity. Acts upstream of or within P granule organization. Located in P granule. Is expressed in blastodisc; blastomere; and primordial germ cell. Human ortholog(s) of this gene implicated in cataract 36. Orthologous to human TDRD7 (tudor domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See tdrd7a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (12195730..12228117)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11508923..11541317)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 Neighboring gene STRA6-like Neighboring gene tropomodulin 1 Neighboring gene complexin 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish. Takeda Y, et al. PLoS One, 2009 Oct 19. PMID 19838299, Free PMC Article
    2. Zebrafish dead end possesses ATPase activity that is required for primordial germ cell development. Liu W, et al. FASEB J, 2010 Aug. PMID 20371629, Free PMC Article
    3. Conserved mechanisms for germ cell-specific localization of nanos3 transcripts in teleost species with aquaculture significance. Škugor A, et al. Mar Biotechnol (NY), 2014 Jun. PMID 24091820
    4. A controllable on-off strategy for the reproductive containment of fish. Zhang Y, et al. Sci Rep, 2015 Jan 5. PMID 25556821, Free PMC Article
    5. Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430. Mishima Y, et al. Curr Biol, 2006 Nov 7. PMID 17084698, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within P granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lens fiber cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lens morphogenesis in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lens morphogenesis in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-transcriptional regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tudor domain-containing protein 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099343.1 → NP_001092813.1  tudor domain-containing protein 7A

      Status: VALIDATED

      Source sequence(s)
      CR388406
      UniProtKB/Swiss-Prot
      A6NAF9, Q7ZTW1
      UniProtKB/TrEMBL
      A0A8M1NF29, F1QTF8
      Related
      ENSDARP00000040306.7, ENSDART00000040307.9
      Conserved Domains (6) summary
      cd04508
      Location:712 → 757
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd09973
      Location:206 → 271
      LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09974
      Location:367 → 434
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09986
      Location:4 → 91
      LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
      smart00333
      Location:520 → 573
      TUDOR; Tudor domain
      pfam00567
      Location:465 → 587
      TUDOR; Tudor domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      12195730..12228117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_213105.1: Suppressed sequence

      Description
      NM_213105.1: This RefSeq was removed because there is insufficient support for the transcript and protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NAF9.2 GenPept UniProtKB/Swiss-Prot:A6NAF9

    Gene LinkOut

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