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    caspa caspase a [ Danio rerio (zebrafish) ]

    Gene ID: 57933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    caspaprovided by ZNC
    Official Full Name
    caspase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000616-3
    See related
    Ensembl:ENSDARG00000008165 AllianceGenome:ZFIN:ZDB-GENE-000616-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    casp1; caspy; fa93b02; wu:fa93b02; zgc:109869
    Summary
    Enables Pyrin domain binding activity and cysteine-type endopeptidase activity. Involved in self proteolysis. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; innate immune response; and pyroptotic inflammatory response. Part of NLRP1 inflammasome complex. Is expressed in several structures, including digestive system; heart; hematopoietic system; integument; and male organism. Orthologous to several human genes including CASP4 (caspase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See caspa in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (41993556..42004481, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (42043524..42054449, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1A Neighboring gene si:ch211-225p5.8 Neighboring gene PYD and CARD domain containing Neighboring gene ETS1-related protein Neighboring gene Fli-1 proto-oncogene, ETS transcription factor-related sequence

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Roles of inflammatory caspases during processing of zebrafish interleukin-1β in Francisella noatunensis infection. Vojtech LN, et al. Infect Immun, 2012 Aug. PMID 22689811, Free PMC Article
    2. Optogenetic activators of apoptosis, necroptosis, and pyroptosis. Shkarina K, et al. J Cell Biol, 2022 Jun 6. PMID 35420640, Free PMC Article
    3. Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production. Molagoda IMN, et al. Antioxidants (Basel), 2021 Jul 28. PMID 34439462, Free PMC Article
    4. Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish. Chen W, et al. J Immunol, 2021 Apr 15. PMID 33712519
    5. Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts. Liew N, et al. Nat Commun, 2017 Apr 20. PMID 28425465, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The fish caspase-1 homolog Caspy, but not the caspase-4/11 homolog Caspy2, interacts with zebrafish ASC through homotypic PYD-PYD interactions, which differ from those in mammals.
      Title: Functional and structural characterization of zebrafish ASC.
    2. role in pharyngeal arch development
      Title: Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Pyrin domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of positive regulation of protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of positive regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyroptotic inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in self proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NLRP1 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NLRP1 inflammasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NLRP1 inflammasome complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of canonical inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of canonical inflammasome complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caspase a
    Names
    caspase 1
    NP_571580.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131505.2 → NP_571580.1  caspase a

      See identical proteins and their annotated locations for NP_571580.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095022
      UniProtKB/Swiss-Prot
      A0A2U9DQN4, Q9I9L7
      Related
      ENSDARP00000034228.7, ENSDART00000034544.9
      Conserved Domains (2) summary
      cd00032
      Location:134 → 380
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cl14633
      Location:6 → 85
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      41993556..42004481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I9L7.1 GenPept UniProtKB/Swiss-Prot:Q9I9L7

    Gene LinkOut

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