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    ncam2 neural cell adhesion molecule 2 [ Danio rerio (zebrafish) ]

    Gene ID: 114441, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ncam2provided by ZNC
    Official Full Name
    neural cell adhesion molecule 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010822-1
    See related
    Ensembl:ENSDARG00000017466 AllianceGenome:ZFIN:ZDB-GENE-010822-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zOCAM; sb:eu836
    Summary
    Acts upstream of or within response to hypoxia. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in brain; sensory system; and swim bladder. Orthologous to human NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ncam2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (35169237..35557365, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (35360055..35748211, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:dkey-192g7.3 Neighboring gene amyloid beta (A4) precursor protein b Neighboring gene zona pellucida glycoprotein 2, like 1 Neighboring gene SON DNA and RNA binding protein a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system. Langhauser M, et al. Glycobiology, 2012 Feb. PMID 21890892
    2. A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Staudt N, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25490391, Free PMC Article
    3. Nlcam modulates midline convergence during anterior neural plate morphogenesis. Brown KE, et al. Dev Biol, 2010 Mar 1. PMID 20005219
    4. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. Manchenkov T, et al. G3 (Bethesda), 2015 Apr 3. PMID 25840431, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neural cell adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131830.2 → NP_571905.1  neural cell adhesion molecule 2 precursor

      See identical proteins and their annotated locations for NP_571905.1

      Status: PROVISIONAL

      Source sequence(s)
      AY029403
      UniProtKB/TrEMBL
      B3DGA0, Q90YM0
      Related
      ENSDARP00000091454.4, ENSDART00000100681.5
      Conserved Domains (7) summary
      cd05866
      Location:20 → 111
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      smart00408
      Location:127 → 187
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:411 → 488
      IG_like; Immunoglobulin like
      cd00063
      Location:494 → 586
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:213 → 296
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:616 → 675
      fn3; Fibronectin type III domain
      cl11960
      Location:298 → 395
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      35169237..35557365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167807.5 → XP_005167864.1  neural cell adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BF98
      Conserved Domains (7) summary
      cd05866
      Location:20 → 111
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      smart00408
      Location:127 → 187
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:411 → 488
      IG_like; Immunoglobulin like
      cd00063
      Location:494 → 586
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:213 → 296
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:616 → 675
      fn3; Fibronectin type III domain
      cl11960
      Location:298 → 395
      Ig; Immunoglobulin domain

    2. XM_068223276.1 → XP_068079377.1  neural cell adhesion molecule 2 isoform X2

    3. XM_005167809.5 → XP_005167866.1  neural cell adhesion molecule 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BFW0
      Conserved Domains (7) summary
      cd05866
      Location:20 → 111
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      smart00408
      Location:127 → 187
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:411 → 488
      IG_like; Immunoglobulin like
      cd00063
      Location:494 → 586
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:213 → 296
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:616 → 675
      fn3; Fibronectin type III domain
      cl11960
      Location:298 → 395
      Ig; Immunoglobulin domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394760.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      469878..597062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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