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    casp2 caspase 2, apoptosis-related cysteine peptidase [ Danio rerio (zebrafish) ]

    Gene ID: 373118, updated on 14-Nov-2024

    Summary

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    Official Symbol
    casp2provided by ZNC
    Official Full Name
    caspase 2, apoptosis-related cysteine peptidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030825-3
    See related
    Ensembl:ENSDARG00000062052 AllianceGenome:ZFIN:ZDB-GENE-030825-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of apoptotic process; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be active in cytoplasm. Is expressed in digestive system; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human CASP2 (caspase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See casp2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (17550229..17578432, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (17642100..17670484, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 131 member Bb Neighboring gene chloride channel, voltage-sensitive 1b Neighboring gene uncharacterized LOC137487837 Neighboring gene mannose-6-phosphate receptor (cation dependent)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Panoramic dental X-ray exposure leads to oxidative stress, inflammation and apoptosis-mediated developmental defects in zebrafish embryos. Karagöz A, et al. J Stomatol Oral Maxillofac Surg, 2023 Dec. PMID 37866507
    2. Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish. Eğimezer G, et al. Hum Exp Toxicol, 2020 Jul. PMID 32054343
    3. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures. Luzio A, et al. Aquat Toxicol, 2016 Aug. PMID 27337697
    4. The cellular responses of autophagy, apoptosis, and 5-methylcytosine level in zebrafish cells upon nutrient deprivation stress. Fan X, et al. Chemosphere, 2020 Feb. PMID 31590028
    5. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Espín R, et al. Dis Model Mech, 2013 Mar. PMID 22956347, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in endothelial cells that bypasses caspase-3.
      Title: TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cysteine-type endopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caspase-2
    Names
    caspase 2, apoptosis-related cysteine protease
    NP_001036160.1
    XP_005157976.1
    XP_009290451.1
    XP_017206813.1
    XP_068070011.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042695.1 → NP_001036160.1  caspase-2

      See identical proteins and their annotated locations for NP_001036160.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ812119
      UniProtKB/TrEMBL
      B3DIG1, E7F2V8, Q0PKX3
      Related
      ENSDARP00000148777.1, ENSDART00000186475.1
      Conserved Domains (2) summary
      cd00032
      Location:158 → 428
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08332
      Location:7 → 94
      CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      17550229..17578432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292176.4 → XP_009290451.1  caspase-2 isoform X2

      See identical proteins and their annotated locations for XP_009290451.1

      UniProtKB/TrEMBL
      B3DIG1, E7F2V8, Q0PKX3
      Related
      ENSDARP00000108155.2, ENSDART00000128388.4
      Conserved Domains (2) summary
      cd00032
      Location:158 → 428
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08332
      Location:7 → 94
      CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

    2. XM_005157919.5 → XP_005157976.1  caspase-2 isoform X1

      UniProtKB/TrEMBL
      A0A288CG41, A0A8N7XJ01, F1Q7C2
      Related
      ENSDARP00000105801.3, ENSDART00000122212.4
      Conserved Domains (2) summary
      cd00032
      Location:158 → 430
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08332
      Location:7 → 94
      CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

    3. XM_068213910.1 → XP_068070011.1  caspase-2 isoform X2

    4. XM_017351324.3 → XP_017206813.1  caspase-2 isoform X1

      UniProtKB/TrEMBL
      A0A288CG41, A0A8N7XJ01, F1Q7C2
      Related
      ENSDARP00000115348.2, ENSDART00000137215.3
      Conserved Domains (2) summary
      cd00032
      Location:158 → 430
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08332
      Location:7 → 94
      CARD_CASP2; Caspase activation and recruitment domain of Caspase-2
    Nucleotide Protein Strain
    Heading Accession and Version

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