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    akr1a1b aldo-keto reductase family 1, member A1b (aldehyde reductase) [ Danio rerio (zebrafish) ]

    Gene ID: 799805, updated on 2-Nov-2024

    Summary

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    Official Symbol
    akr1a1bprovided by ZNC
    Official Full Name
    aldo-keto reductase family 1, member A1b (aldehyde reductase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-118
    See related
    Ensembl:ENSDARG00000052030 AllianceGenome:ZFIN:ZDB-GENE-050417-118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    akr1a1; zgc:110225
    Summary
    Enables aldo-keto reductase (NADPH) activity. Involved in glucose homeostasis and regulation of gluconeogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; immune system; liver; and muscle. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See akr1a1b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (33918813..33925432, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (33934123..33940739, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 17 Neighboring gene nuclear autoantigenic sperm protein (histone-binding) Neighboring gene pre-mRNA processing factor 38A Neighboring gene origin recognition complex, subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of Tilapia (Oreochromis niloticus) aldehyde reductase (AKR1A1) gene, promoter and expression pattern in benzo-a-pyrene exposed fish. Hassanin A, et al. Toxicol Mech Methods, 2017 Jan. PMID 27800707
    2. Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. Li X, et al. iScience, 2020 Dec 18. PMID 33251496, Free PMC Article
    3. Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Li C, et al. Fish Physiol Biochem, 2022 Dec. PMID 36161547
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110225

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables S-nitrosoglutathione reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldo-keto reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables all-trans-retinol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular detoxification of aldehyde ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member A1-B
    Names
    S-nitroso-CoA reductase
    alcohol dehydrogenase [NADP(+)] B
    alcohol dehydrogenase [NADP+] B
    aldehyde reductase-B
    aldo-keto reductase family 1, member A1
    scorR
    NP_001017640.1
    XP_005166342.1
    XP_005166343.1
    XP_005166344.1
    XP_005166346.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017640.1 → NP_001017640.1  aldo-keto reductase family 1 member A1-B

      See identical proteins and their annotated locations for NP_001017640.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092808
      UniProtKB/Swiss-Prot
      Q568L5
      Related
      ENSDARP00000119785.1, ENSDART00000145019.3
      Conserved Domains (2) summary
      COG0656
      Location:1 → 297
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:9 → 293
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      33918813..33925432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166286.5 → XP_005166343.1  aldo-keto reductase family 1 member A1-B isoform X2

      See identical proteins and their annotated locations for XP_005166343.1

      UniProtKB/TrEMBL
      A0A8M2BDV8, F1R3J0
      Related
      ENSDARP00000122715.1, ENSDART00000141822.3
      Conserved Domains (2) summary
      COG0656
      Location:2 → 299
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:11 → 295
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    2. XM_005166285.4 → XP_005166342.1  aldo-keto reductase family 1 member A1-B isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDN5
      Related
      ENSDARP00000113164.1, ENSDART00000137268.3
      Conserved Domains (2) summary
      COG0656
      Location:27 → 324
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:36 → 320
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    3. XM_005166289.5 → XP_005166346.1  aldo-keto reductase family 1 member A1-B isoform X2

      See identical proteins and their annotated locations for XP_005166346.1

      UniProtKB/TrEMBL
      A0A8M2BDV8, F1R3J0
      Conserved Domains (2) summary
      COG0656
      Location:2 → 299
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:11 → 295
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    4. XM_005166287.4 → XP_005166344.1  aldo-keto reductase family 1 member A1-B isoform X2

      See identical proteins and their annotated locations for XP_005166344.1

      UniProtKB/TrEMBL
      A0A8M2BDV8, F1R3J0
      Conserved Domains (2) summary
      COG0656
      Location:2 → 299
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:11 → 295
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395259.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      224179..232005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q568L5.1 GenPept UniProtKB/Swiss-Prot:Q568L5

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