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    mbpb myelin basic protein b [ Danio rerio (zebrafish) ]

    Gene ID: 368319, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mbpbprovided by ZNC
    Official Full Name
    myelin basic protein bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030429-21
    See related
    Ensembl:ENSDARG00000089413 AllianceGenome:ZFIN:ZDB-GENE-030429-21
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb183; wu:fb71b08; si:dkey-241k19.2
    Summary
    This gene encodes the classic myelin basic protein, a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. In humans (see PubMed ID 7504278), related transcripts found in bone marrow and the immune system arise from a longer form of the gene (referred to as Golli-MBP), which includes additional exons upstream of the exons of classic myelin basic protein. Similar to human, the zebrafish gene is characterized by alternate transcription start sites and splicing, although the full-length nature of all has yet to be determined. [provided by RefSeq, Sep 2012]
    Orthologs
    all
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    Genomic context

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    See mbpb in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (6803324..6849800, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (6862646..6909122, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 407 Neighboring gene zinc finger protein 236 Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 2b Neighboring gene phosphomevalonate kinase Neighboring gene ELL associated factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of myelin basic protein, an abundant structural myelin component. Nawaz S, et al. Glia, 2013 Aug. PMID 24040667
    2. The 3'UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish. Torvund-Jensen J, et al. Front Mol Neurosci, 2018. PMID 29946237, Free PMC Article
    3. yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development. Blanco-Sánchez B, et al. PLoS Genet, 2020 Jun. PMID 32544203, Free PMC Article
    4. Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Yatsuka H, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33333712
    5. Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain. Xing L, et al. J Biol Chem, 2022 Oct. PMID 36063998, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myelin basic protein b
    Names
    Golli

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271459.1 → NP_001258388.1  myelin basic protein b isoform 2

      See identical proteins and their annotated locations for NP_001258388.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains three exons unique to Golli-MBP and exon 1 of the classic myelin basic protein. It encodes a Golli-MBP isoform (2).
      Source sequence(s)
      AL845419, CB354061, CU459091
      UniProtKB/TrEMBL
      A0A8M1P3U7, E7EYA2
      Related
      ENSDARP00000124557.1, ENSDART00000149778.2

    2. NM_001271460.1 → NP_001258389.1  myelin basic protein b isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a classic myelin basic protein isoform (1).
      Source sequence(s)
      CU459091, EH585066
      UniProtKB/TrEMBL
      A0A8M1NZT7, F8W4C1
      Related
      ENSDARP00000124242.1, ENSDART00000149570.2
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 121
      Myelin_MBP; Myelin basic protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      6803324..6849800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157835.3 → XP_005157892.1  myelin basic protein b isoform X1

      See identical proteins and their annotated locations for XP_005157892.1

      UniProtKB/TrEMBL
      A0A8M2B444

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394952.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      7216..24089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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