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    lpcat2 lysophosphatidylcholine acyltransferase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 553683, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lpcat2provided by ZNC
    Official Full Name
    lysophosphatidylcholine acyltransferase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-229
    See related
    Ensembl:ENSDARG00000053010 AllianceGenome:ZFIN:ZDB-GENE-050522-229
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    aytl1; zgc:112165
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and 1-alkylglycerophosphocholine O-acetyltransferase activity. Predicted to be involved in phospholipid metabolic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human LPCAT2 (lysophosphatidylcholine acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lpcat2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (35386257..35408332, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (35114575..35136890, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 4 Neighboring gene solute carrier family 6 member 2 Neighboring gene uncharacterized LOC101885114 Neighboring gene matrix metallopeptidase 2 Neighboring gene uncharacterized LOC110439935 Neighboring gene iroquois homeobox 6a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene expression profiling reveals a conserved microglia signature in larval zebrafish. Mazzolini J, et al. Glia, 2020 Feb. PMID 31508850, Free PMC Article
    2. On the tubulin polymerization promoting proteins of zebrafish. Orosz F. Biochem Biophys Res Commun, 2015 Feb 13. PMID 25576359
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC112165

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plasmalogen synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidylcholine acyltransferase 2
    Names
    1-AGP acyltransferase 11
    1-AGPAT 11
    1-acylglycerol-3-phosphate O-acyltransferase 11
    1-acylglycerophosphocholine O-acyltransferase
    1-alkenylglycerophosphocholine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase
    LPC acyltransferase 2
    LPCAT-2
    acetyl-CoA:lyso-PAF acetyltransferase
    acetyl-CoA:lyso-platelet-activating factor acetyltransferase
    acyltransferase like 1
    lyso-PAF acetyltransferase
    lysoPAFAT
    lysoPC acyltransferase 2
    NP_001018492.1
    XP_005169036.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020656.1 → NP_001018492.1  lysophosphatidylcholine acyltransferase 2

      See identical proteins and their annotated locations for NP_001018492.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095679
      UniProtKB/Swiss-Prot
      Q502J0
      Related
      ENSDARP00000069449.3, ENSDART00000074963.4
      Conserved Domains (5) summary
      cd07991
      Location:98 → 309
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:49 → 297
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      cd00051
      Location:418 → 473
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:415 → 473
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:316 → 406
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      35386257..35408332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168979.5 → XP_005169036.1  lysophosphatidylcholine acyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BG99, F1Q8S6
      Related
      ENSDARP00000111397.1, ENSDART00000128334.4
      Conserved Domains (5) summary
      cd07991
      Location:98 → 309
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:49 → 297
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      cd00051
      Location:418 → 473
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:415 → 473
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:316 → 406
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q502J0.1 GenPept UniProtKB/Swiss-Prot:Q502J0

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