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    polg2 polymerase (DNA directed), gamma 2, accessory subunit [ Danio rerio (zebrafish) ]

    Gene ID: 100150674, updated on 2-Nov-2024

    Summary

    Official Symbol
    polg2provided by ZNC
    Official Full Name
    polymerase (DNA directed), gamma 2, accessory subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-116
    See related
    Ensembl:ENSDARG00000074933 AllianceGenome:ZFIN:ZDB-GENE-060810-116
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7158733; si:ch211-157f15.3
    Summary
    Predicted to be involved in mitochondrial DNA replication. Predicted to be active in mitochondrion. Is expressed in eye and retina. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 16; and mitochondrial DNA depletion syndrome 16B. Orthologous to human POLG2 (DNA polymerase gamma 2, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See polg2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (23010381..23024436)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (17912434..17928114)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene nucleolar protein 11 Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene signal recognition particle 68 Neighboring gene envoplakin a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in mitochondrial DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DNA polymerase subunit gamma-2, mitochondrial; DNA polymerase subunit gamma-2
    XP_001922359.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      23010381..23024436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001922324.8XP_001922359.2  DNA polymerase subunit gamma-2

      UniProtKB/TrEMBL
      A0A8M1QV74, E7F4P9
      Related
      ENSDARP00000099588.2, ENSDART00000113116.5
      Conserved Domains (3) summary
      PRK04173
      Location:40436
      PRK04173; glycyl-tRNA synthetase; Provisional
      cl00266
      Location:320438
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
      cl00268
      Location:40309
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...