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    bud23 BUD23 rRNA methyltransferase and ribosome maturation factor [ Danio rerio (zebrafish) ]

    Gene ID: 572367, updated on 2-Nov-2024

    Summary

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    Official Symbol
    bud23provided by ZNC
    Official Full Name
    BUD23 rRNA methyltransferase and ribosome maturation factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-68
    See related
    Ensembl:ENSDARG00000063596 AllianceGenome:ZFIN:ZDB-GENE-070410-68
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wbscr22; zgc:162306
    Summary
    Predicted to enable rRNA (guanine) methyltransferase activity. Predicted to be involved in rRNA (guanine-N7)-methylation. Predicted to act upstream of or within methylation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bud23 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1749843..1765116, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1784934..1800207, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene RAB guanine nucleotide exchange factor (GEF) 1, like Neighboring gene syntaxin 1A (brain) Neighboring gene cullin 3b Neighboring gene family with sequence similarity 124 member B Neighboring gene matrix metallopeptidase 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (guanine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (guanine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rRNA (guanine-N7)-methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    18S rRNA (guanine-N(7))-methyltransferase
    Names
    Williams Beuren syndrome chromosome region 22
    NP_001076348.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082879.1 → NP_001076348.1  18S rRNA (guanine-N(7))-methyltransferase

      See identical proteins and their annotated locations for NP_001076348.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133941
      UniProtKB/TrEMBL
      A0A8M1NBY6, A3KNP4
      Related
      ENSDARP00000087506.4, ENSDART00000093074.6
      Conserved Domains (2) summary
      pfam08241
      Location:58 → 133
      Methyltransf_11; Methyltransferase domain
      pfam12589
      Location:204 → 280
      WBS_methylT; Methyltransferase involved in Williams-Beuren syndrome

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      1749843..1765116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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