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    bub1bb BUB1 mitotic checkpoint serine/threonine kinase Bb [ Danio rerio (zebrafish) ]

    Gene ID: 567006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bub1bbprovided by ZNC
    Official Full Name
    BUB1 mitotic checkpoint serine/threonine kinase Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030829-51
    See related
    Ensembl:ENSDARG00000074927 AllianceGenome:ZFIN:ZDB-GENE-030829-51
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb730
    Summary
    Predicted to enable kinase activity. Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling and phosphorylation. Is expressed in hindbrain; optic tectum; pectoral fin musculature; proliferative region; and retina. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bub1bb in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (2127009..2148106)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (1950200..1971293)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14D Neighboring gene zinc finger, FYVE domain containing 19 Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ankyrin repeat domain 63

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
    2. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitotic checkpoint serine/threonine-protein kinase BUB1 beta
    Names
    budding uninhibited by benzimidazoles 1 homolog beta b
    XP_695384.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      2127009..2148106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_690292.9 → XP_695384.3  mitotic checkpoint serine/threonine-protein kinase BUB1 beta

      UniProtKB/TrEMBL
      A0A8N7T876, E7F5T9
      Related
      ENSDARP00000099195.2, ENSDART00000110529.4
      Conserved Domains (1) summary
      pfam08311
      Location:45 → 165
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
    Nucleotide Protein Strain
    Heading Accession and Version

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