mybl2b v-myb avian myeloblastosis viral oncogene homolog-like 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mybl2bprovided by ZNC
Official Full Name: v-myb avian myeloblastosis viral oncogene homolog-like 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041007-1
See related: Ensembl:ENSDARG00000032264 AllianceGenome:ZFIN:ZDB-GENE-041007-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mybl2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in mitotic cell cycle and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in heart. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (1551572..1574656)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (1525075..1548068)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.
Title: A Mettl16/m(6)A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.
loss-of-function mutation (crb) in bmyb causes defects in mitotic progression and spindle formation and genome instability in embryos, and cancer susceptibility in adult crb heterozygotes
Title: A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.

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General gene information

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Markers

fj79e06.x1 (e-PCR)
- UniSTS:199929

fj79e12.y1 (e-PCR)
- UniSTS:199931

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: v-myb avian myeloblastosis viral oncogene homolog-like 2b

Names: MOL2; b-myb; crash&burn; crb; myeloblastosis oncogene-like 2; v-myb avian myeloblastosis viral oncogene homolog-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003867.2 → NP_001003867.2 v-myb avian myeloblastosis viral oncogene homolog-like 2b

See identical proteins and their annotated locations for NP_001003867.2

Status: PROVISIONAL

Source sequence(s)

BC098588

UniProtKB/TrEMBL

Q4KMF7

Related

ENSDARP00000157084.1, ENSDART00000185383.1

Conserved Domains (4) summary

smart00717
Location:84 → 132

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:84 → 130

Myb_DNA-binding; Myb-like DNA-binding domain

pfam09316
Location:380 → 537

Cmyb_C; C-myb, C-terminal

pfam13921
Location:35 → 95

Myb_DNA-bind_6; Myb-like DNA-binding domain