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    n4bp2l2 NEDD4 binding protein 2-like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 565380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    n4bp2l2provided by ZNC
    Official Full Name
    NEDD4 binding protein 2-like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-131121-433
    See related
    Ensembl:ENSDARG00000103507 AllianceGenome:ZFIN:ZDB-GENE-131121-433
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-26o16.6
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human N4BP2L2 (NEDD4 binding protein 2 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See n4bp2l2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (33809823..33818862, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (33951844..33960931, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 9B Neighboring gene PDS5 cohesin associated factor B Neighboring gene matrix metallopeptidase 13b Neighboring gene inositol polyphosphate-5-phosphatase Ka

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genomic organization and evolution of olfactory receptors and trace amine-associated receptors in channel catfish, Ictalurus punctatus. Gao S, et al. Biochim Biophys Acta Gen Subj, 2017 Mar. PMID 27773705
    2. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NEDD4-binding protein 2-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      33809823..33818862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_688657.9 → XP_693749.2  NEDD4-binding protein 2-like 2

      UniProtKB/TrEMBL
      A0A0R4IMJ9, A0A8N7T7I7
      Related
      ENSDARP00000136822.1, ENSDART00000158325.2
      Conserved Domains (2) summary
      pfam13671
      Location:297 → 431
      AAA_33; AAA domain
      cl17190
      Location:294 → 431
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials