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    polr1b RNA polymerase I subunit B [ Danio rerio (zebrafish) ]

    Gene ID: 325603, updated on 9-Dec-2024

    Summary

    Official Symbol
    polr1bprovided by ZNC
    Official Full Name
    RNA polymerase I subunit Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1598
    See related
    Ensembl:ENSDARG00000077469 AllianceGenome:ZFIN:ZDB-GENE-040426-1598
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66298; wu:fc91a05
    Summary
    Enables RNA polymerase I activity. Involved in neural crest cell migration. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including alar plate midbrain region; eye; liver; musculature system; and optic tectum. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Orthologous to human POLR1B (RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See polr1b in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (41917625..41940467)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (41791655..41814497)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate multikinase a Neighboring gene CDGSH iron sulfur domain 1 Neighboring gene N-acetylneuraminic acid phosphatase Neighboring gene cytochrome P450, family 1, subfamily B, polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC66298, MGC113960, MGC158198, MGC192771

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase I activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase I subunit RPA2
    Names
    RNA polymerase I polypeptide B
    RNA polymerase I subunit 2
    polymerase (RNA) I polypeptide B
    NP_956812.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200518.2NP_956812.2  DNA-directed RNA polymerase I subunit RPA2

      See identical proteins and their annotated locations for NP_956812.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097040
      UniProtKB/Swiss-Prot
      B8JKD7
      UniProtKB/TrEMBL
      Q4V967
      Related
      ENSDARP00000100185.3, ENSDART00000114741.5
      Conserved Domains (3) summary
      COG0085
      Location:161132
      RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
      cd00653
      Location:371130
      RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
      pfam06883
      Location:561614
      RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      41917625..41940467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394888.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      91622..113728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)