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    mmab metabolism of cobalamin associated B [ Danio rerio (zebrafish) ]

    Gene ID: 557077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mmabprovided by ZNC
    Official Full Name
    metabolism of cobalamin associated Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-232
    See related
    Ensembl:ENSDARG00000068344 AllianceGenome:ZFIN:ZDB-GENE-060526-232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-189p24.5
    Summary
    Predicted to enable corrinoid adenosyltransferase activity. Human ortholog(s) of this gene implicated in inherited metabolic disorder and methylmalonic acidemia cblB type. Orthologous to human MMAB (metabolism of cobalamin associated B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mmab in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (19489581..19494048, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (18985781..18990248, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3B Neighboring gene aldehyde dehydrogenase 3 family, member B4 Neighboring gene mevalonate kinase Neighboring gene family with sequence similarity 222 member Aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC162262

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables corrinoid adenosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables corrinoid adenosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    corrinoid adenosyltransferase MMAB
    Names
    methylmalonic aciduria (cobalamin deficiency) cblB type
    NP_001076278.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082809.1 → NP_001076278.1  corrinoid adenosyltransferase MMAB

      Status: PROVISIONAL

      Source sequence(s)
      BX510366
      UniProtKB/TrEMBL
      A0A8M1NBZ7, A2BGN0
      Related
      ENSDARP00000089565.4, ENSDART00000098795.5
      Conserved Domains (1) summary
      pfam01923
      Location:50 → 218
      Cob_adeno_trans; Cobalamin adenosyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      19489581..19494048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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