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    pde10a phosphodiesterase 10A [ Danio rerio (zebrafish) ]

    Gene ID: 394077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pde10aprovided by ZNC
    Official Full Name
    phosphodiesterase 10Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1115
    See related
    Ensembl:ENSDARG00000003449 AllianceGenome:ZFIN:ZDB-GENE-040426-1115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56689
    Summary
    Predicted to enable 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Predicted to act upstream of or within signal transduction. Is expressed in chordo neural hinge; epidermis; nervous system; and notochord. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pde10a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (4466185..4627946)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (4337633..4492442)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene si:ch211-130h14.4 Neighboring gene uncharacterized LOC137487355 Neighboring gene uncharacterized LOC137487356 Neighboring gene T-box transcription factor Tb Neighboring gene phospholipase A2, group XIIB Neighboring gene C1D nuclear receptor corepressor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. PDE10A Inhibition Reduces the Manifestation of Pathology in DMD Zebrafish and Represses the Genetic Modifier PITPNA. Lambert MR, et al. Mol Ther, 2021 Mar 3. PMID 33221436, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC56689

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    NP_957396.2
    XP_017214212.1
    XP_017214213.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201102.2 → NP_957396.2  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

      Status: VALIDATED

      Source sequence(s)
      BX323866, CABZ01035960, CR854838
      UniProtKB/TrEMBL
      A0A0R4IJT4, A0A8M1PC69, A0A8M6Z9J5
      Related
      ENSDARP00000134187.1, ENSDART00000161684.2
      Conserved Domains (3) summary
      smart00065
      Location:277 → 432
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      COG2203
      Location:105 → 257
      FhlA; GAF domain [Signal transduction mechanisms]
      pfam00233
      Location:524 → 755
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      4466185..4627946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358723.3 → XP_017214212.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z293, A0A8M6Z9J5

    2. XM_017358724.3 → XP_017214213.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z3S4, A0A8M6Z9J5
    Nucleotide Protein Strain
    Heading Accession and Version

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