siah2l seven in absentia homolog 2 (Drosophila)-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: siah2lprovided by ZNC
Official Full Name: seven in absentia homolog 2 (Drosophila)-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030922-1
See related: Ensembl:ENSDARG00000044381 AllianceGenome:ZFIN:ZDB-GENE-030922-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: siaz; zgc:66284
Summary: Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of circadian rhythm. Predicted to act upstream of or within rhythmic process. Predicted to be active in cytoplasm. Is expressed in several structures, including dorsal aorta; male organism; nervous system; optic fissure; and otic vesicle. Orthologous to human SIAH2 (siah E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (38657966..38717856, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (38610260..38670150, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The E3 ubiquitin ligase activity of Siah2 is required for Nodal signaling during zebrafish embryonic development.
Title: Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development.
sinup expression is tightly regulated during early embryonic development for the proper neural plate formation
Title: Sinup, a novel Siaz-interacting nuclear protein, modulates neural plate formation in the zebrafish embryos.
the N-terminal RING and central domain of Siaz are sufficient to block the G2/M phase transition
Title: The RING domain of Siaz, the zebrafish homologue of Drosophila seven in absentia, is essential for cellular growth arrest.

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General gene information

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Markers

fj83c10.x1 (e-PCR)
- UniSTS:200047

fd05e03.x1 (e-PCR)
- UniSTS:194959

Z4425 (e-PCR)
- UniSTS:7577

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Siah2

Names: RING-type E3 ubiquitin transferase SIAH2; seven in absentia 2-like; seven in absentia homolog 2-like; siah-2; ubiquitin ligase siah2

NP_956721.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200427.2 → NP_956721.2 E3 ubiquitin-protein ligase Siah2

Status: VALIDATED

Source sequence(s)

AL935199, CF996038, CU694657, DT068839

UniProtKB/TrEMBL

A0A8N1TYI4, G8JL17

Related

ENSDARP00000065168.4, ENSDART00000065169.6

Conserved Domains (1) summary

pfam03145
Location:130 → 326

Sina; Seven in absentia protein family