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    eif5a eukaryotic translation initiation factor 5A [ Danio rerio (zebrafish) ]

    Gene ID: 406464, updated on 2-Nov-2024

    Summary

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    Official Symbol
    eif5aprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 5Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2229
    See related
    Ensembl:ENSDARG00000017235 AllianceGenome:ZFIN:ZDB-GENE-040426-2229
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eIF-5A1; eIF-5A-1; zgc:77099; wu:fb17e01; wu:fb63h04; wu:fk81e04
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within positive regulation of translational elongation; positive regulation of translational termination; and translational initiation. Predicted to be located in endoplasmic reticulum membrane and nucleus. Is expressed in endoderm; intestine; liver; pancreas; and swim bladder. Orthologous to several human genes including EIF5A (eukaryotic translation initiation factor 5A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See eif5a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (26481966..26485311, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (26336807..26340299, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 14b Neighboring gene ribosomal protein L22-like 1 Neighboring gene TRAF2 and NCK interacting kinase b Neighboring gene rho-associated protein kinase 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine. Faundes V, et al. Nat Commun, 2021 Feb 5. PMID 33547280, Free PMC Article
    2. Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. Carvalho CM, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439725, Free PMC Article
    3. Polyamine biosynthesis is critical for growth and differentiation of the pancreas. Mastracci TL, et al. Sci Rep, 2015 Aug 24. PMID 26299433, Free PMC Article
    4. A molecular network of conserved factors keeps ribosomes dormant in the egg. Leesch F, et al. Nature, 2023 Jan. PMID 36653451, Free PMC Article
    5. Zebrafish promoter microarrays identify actively transcribed embryonic genes. Wardle FC, et al. Genome Biol, 2006. PMID 16889661, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5A-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213185.1 → NP_998350.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_998350.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067190
      UniProtKB/Swiss-Prot
      F6NH52, F6NKL5, Q6NX89
      Related
      ENSDARP00000027654.7, ENSDART00000009609.10
      Conserved Domains (2) summary
      PLN03107
      Location:1 → 151
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:85 → 153
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      26481966..26485311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162775.4 → XP_005162832.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_005162832.1

      UniProtKB/Swiss-Prot
      F6NH52, F6NKL5, Q6NX89
      Related
      ENSDARP00000099088.3, ENSDART00000113739.5
      Conserved Domains (2) summary
      PLN03107
      Location:1 → 151
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:85 → 153
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...

    2. XM_005162776.4 → XP_005162833.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_005162833.1

      UniProtKB/Swiss-Prot
      F6NH52, F6NKL5, Q6NX89
      Related
      ENSDARP00000118000.1, ENSDART00000133782.3
      Conserved Domains (2) summary
      PLN03107
      Location:1 → 151
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:85 → 153
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NX89.1 GenPept UniProtKB/Swiss-Prot:Q6NX89

    Gene LinkOut

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