tp53bp1 tumor protein p53 binding protein, 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tp53bp1provided by ZNC
Official Full Name: tumor protein p53 binding protein, 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3695
See related: Ensembl:ENSDARG00000079000 AllianceGenome:ZFIN:ZDB-GENE-030131-3695
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc50a09; wu:fj67d04; zgc:158452
Summary: Predicted to enable histone binding activity. Predicted to be involved in DNA damage checkpoint signaling and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA damage response. Predicted to be active in nucleus. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (52885599..52933190)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (52610506..52662065)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc50a09 (e-PCR), detects polymorphism
- UniSTS:189261

fb36b05.x1 (e-PCR)
- UniSTS:203143

G39605 (e-PCR)
- UniSTS:31890

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TP53-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080170.1 → NP_001073639.1 TP53-binding protein 1

See identical proteins and their annotated locations for NP_001073639.1

Status: PROVISIONAL

Source sequence(s)

BC129236

UniProtKB/TrEMBL

A0A8M6Z1I8, A1L1W2

Related

ENSDARP00000101125.2, ENSDART00000109973.5

Conserved Domains (2) summary

smart00292
Location:1514 → 1579

BRCT; breast cancer carboxy-terminal domain

cl02573
Location:1248 → 1368

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...