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    psmd1 proteasome 26S subunit, non-ATPase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 554967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psmd1provided by ZNC
    Official Full Name
    proteasome 26S subunit, non-ATPase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-810
    See related
    Ensembl:ENSDARG00000003189 AllianceGenome:ZFIN:ZDB-GENE-040426-810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55818
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in nucleus and proteasome storage granule. Is expressed in head. Orthologous to human PSMD1 (proteasome 26S subunit, non-ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See psmd1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (37631234..37716627)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (37696224..37781619)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488977 Neighboring gene uncharacterized LOC562053 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 2b Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Znf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome. Bao J, et al. Invest Ophthalmol Vis Sci, 2023 May 1. PMID 37256609, Free PMC Article
    2. Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio). Chen XK, et al. Exp Mol Med, 2022 Jul. PMID 35831435, Free PMC Article
    3. Expression profiling and comparative genomics identify a conserved regulatory region controlling midline expression in the zebrafish embryo. Dickmeis T, et al. Genome Res, 2004 Feb. PMID 14718378, Free PMC Article
    4. Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model. Li Y, et al. Dis Model Mech, 2019 Oct 17. PMID 31515263, Free PMC Article
    5. New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. Tseng LC, et al. PLoS One, 2014. PMID 24714733, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55818

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in proteasome storage granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 1
    Names
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201184.2 → NP_957478.2  26S proteasome non-ATPase regulatory subunit 1

      Status: VALIDATED

      Source sequence(s)
      BX571973, EH443001, EH604198, FO704589
      UniProtKB/TrEMBL
      A0A0R4IJ38, A0A8M1PFS1, F1QK93
      Related
      ENSDARP00000006823.8, ENSDART00000007346.9
      Conserved Domains (3) summary
      COG5116
      Location:2 → 945
      RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01851
      Location:652 → 686
      PC_rep; Proteasome/cyclosome repeat
      sd00044
      Location:602 → 625
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      37631234..37716627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353144.3 → XP_017208633.1  26S proteasome non-ATPase regulatory subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YXA0
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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