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    mtnr1ba melatonin receptor type 1Ba [ Danio rerio (zebrafish) ]

    Gene ID: 30669, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtnr1baprovided by ZNC
    Official Full Name
    melatonin receptor type 1Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-157
    See related
    Ensembl:ENSDARG00000053833 AllianceGenome:ZFIN:ZDB-GENE-990415-157
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mt2; mel1b; mtnr1b
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within rhythmic process and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in diencephalic nucleus; male organism; and midbrain. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mtnr1ba in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (41027466..41064007)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (41070070..41106611)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487789 Neighboring gene FAT atypical cadherin 3a Neighboring gene solute carrier family 36 member 4 Neighboring gene single-pass membrane protein with coiled-coil domains 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. White LED Light Exposure Inhibits the Development and Xanthophore Pigmentation of Zebrafish Embryo. Üstündağ ÜV, et al. Sci Rep, 2019 Jul 25. PMID 31346212, Free PMC Article
    2. Cloning of a melatonin-related receptor from human pituitary. Reppert SM, et al. FEBS Lett, 1996 May 20. PMID 8647286
    3. Determining Zebrafish Epitope Reactivity to Commercially Available Antibodies. Villarreal MA, et al. Zebrafish, 2017 Aug. PMID 28318435, Free PMC Article
    4. Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation. Ren DL, et al. J Endocrinol, 2015 Oct. PMID 26303298
    5. Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish. Loganathan K, et al. Zoolog Sci, 2019 Apr 1. PMID 31120653

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables melatonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    melatonin receptor type 1B-A
    Names
    mel-1B-R
    mel-1B-R-A
    mel1b receptor A
    melatonin receptor Mel1b Z6.2
    melatonin receptor Mel1b-19
    melatonin receptor type 1B a
    melatonin receptor type 1B z6.2
    zMel1b-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131395.1 → NP_571470.1  melatonin receptor type 1B-A

      See identical proteins and their annotated locations for NP_571470.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163408
      UniProtKB/Swiss-Prot
      Q804J1, Q90456
      UniProtKB/TrEMBL
      B3DJ99, B3DJC0
      Related
      ENSDARP00000070419.3, ENSDART00000075940.4
      Conserved Domains (2) summary
      pfam00001
      Location:49 → 300
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40 → 145
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      41027466..41064007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90456.2 GenPept UniProtKB/Swiss-Prot:Q90456

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.