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    hao1 hydroxyacid oxidase (glycolate oxidase) 1 [ Danio rerio (zebrafish) ]

    Gene ID: 402827, updated on 14-Nov-2024

    Summary

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    Official Symbol
    hao1provided by ZNC
    Official Full Name
    hydroxyacid oxidase (glycolate oxidase) 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060519-2
    See related
    Ensembl:ENSDARG00000024160 AllianceGenome:ZFIN:ZDB-GENE-060519-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable (S)-2-hydroxy-acid oxidase activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be active in peroxisomal matrix. Orthologous to human HAO1 (hydroxyacid oxidase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hao1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (4030493..4063581)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (3879456..3912544)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene phospholipase C beta 1 Neighboring gene thioredoxin-related transmembrane protein 4 Neighboring gene bone morphogenetic protein 2a Neighboring gene growth differentiation factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Toxicity assessment of atmospheric particulate matter in the Mediterranean and Black Seas open waters. Mesquita SR, et al. Sci Total Environ, 2016 Mar 1. PMID 26745302
    2. Toxic potential of organic constituents of submicron particulate matter (PM1) in an urban road site (Barcelona). Mesquita SR, et al. Environ Sci Pollut Res Int, 2017 Jun. PMID 28508335
    3. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Mesquita SR, et al. Environ Pollut, 2015 Nov. PMID 26298234
    4. Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine. Yang MJ, et al. Virulence, 2020 Dec. PMID 32316833, Free PMC Article
    5. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables (S)-2-hydroxy-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-Hydroxyacid oxidase 1
    NP_001077011.1
    XP_009291053.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083542.1 → NP_001077011.1  2-Hydroxyacid oxidase 1

      See identical proteins and their annotated locations for NP_001077011.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133873
      UniProtKB/TrEMBL
      A4FVH7
      Related
      ENSDARP00000126401.1, ENSDART00000151849.2
      Conserved Domains (2) summary
      cd02809
      Location:10 → 357
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
      pfam01070
      Location:16 → 362
      FMN_dh; FMN-dependent dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      4030493..4063581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292778.4 → XP_009291053.1  2-Hydroxyacid oxidase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AIM9
      Conserved Domains (2) summary
      cd02809
      Location:10 → 304
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
      pfam01070
      Location:16 → 309
      FMN_dh; FMN-dependent dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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