U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lxn latexin [ Danio rerio (zebrafish) ]

    Gene ID: 494053, updated on 3-Dec-2024

    Summary

    Official Symbol
    lxnprovided by ZNC
    Official Full Name
    latexinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-18
    See related
    Ensembl:ENSDARG00000043102 AllianceGenome:ZFIN:ZDB-GENE-041212-18
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    RARRES1; wu:fk66c02; zgc:103612
    Summary
    Predicted to enable metalloendopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be active in extracellular space. Is expressed in annular ligament and corneal endothelium. Orthologous to several human genes including LXN (latexin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See lxn in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1181425..1199336, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1220622..1238189, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y13 Neighboring gene myeloid leukemia factor 1 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene major facilitator superfamily domain containing 1 Neighboring gene karyopherin alpha 4 (importin alpha 3) Neighboring gene schwannomin interacting protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008596.1NP_001008596.1  latexin precursor

      See identical proteins and their annotated locations for NP_001008596.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086837
      UniProtKB/TrEMBL
      Q5PR40
      Related
      ENSDARP00000143725.1, ENSDART00000177869.2
      Conserved Domains (1) summary
      pfam06907
      Location:46259
      Latexin; Latexin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      1181425..1199336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169638.4XP_005169695.1  latexin isoform X4

      UniProtKB/TrEMBL
      A0A8M2BGX5, F1RDP7
      Conserved Domains (1) summary
      pfam06907
      Location:8220
      Latexin; Latexin
    2. XM_021481397.2XP_021337072.1  latexin isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q0C1
      Conserved Domains (1) summary
      pfam06907
      Location:46257
      Latexin
    3. XM_005169637.4XP_005169694.1  latexin isoform X1

      UniProtKB/TrEMBL
      A0A286Y993, A0A8M2BGW6
      Conserved Domains (1) summary
      pfam06907
      Location:46258
      Latexin; Latexin
    4. XM_068213540.1XP_068069641.1  latexin isoform X1

      UniProtKB/TrEMBL
      A0A286Y993, A0A8M2BGW6
    5. XM_068213539.1XP_068069640.1  latexin isoform X1

      UniProtKB/TrEMBL
      A0A286Y993, A0A8M2BGW6
    6. XM_021481398.2XP_021337073.1  latexin isoform X4

      UniProtKB/TrEMBL
      A0A8M2BGX5, F1RDP7
      Related
      ENSDARP00000063284.5, ENSDART00000063285.6
      Conserved Domains (1) summary
      pfam06907
      Location:8220
      Latexin; Latexin
    7. XM_009291320.4XP_009289595.1  latexin isoform X3

      UniProtKB/TrEMBL
      A0A8M3ASB5
      Conserved Domains (1) summary
      pfam06907
      Location:19231
      Latexin; Latexin