cdkn3 cyclin dependent kinase inhibitor 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdkn3provided by ZNC
Official Full Name: cyclin dependent kinase inhibitor 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-060427-2
See related: Ensembl:ENSDARG00000039130 AllianceGenome:ZFIN:ZDB-GENE-060427-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in myotome and somite. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (36612930..36621926, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (36486830..36496120, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 3

NP_001139153.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145681.1 → NP_001139153.1 cyclin-dependent kinase inhibitor 3

Status: PROVISIONAL

Source sequence(s)

BX927407

UniProtKB/TrEMBL

A0A8M1NTA9, A0A8M2B335, B8A6D9

Related

ENSDARP00000057154.6, ENSDART00000057155.8

Conserved Domains (1) summary

cl21483
Location:1 → 163

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...