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    akap1b A kinase (PRKA) anchor protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 556208, updated on 9-Dec-2024

    Summary

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    Official Symbol
    akap1bprovided by ZNC
    Official Full Name
    A kinase (PRKA) anchor protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6844
    See related
    Ensembl:ENSDARG00000006062 AllianceGenome:ZFIN:ZDB-GENE-030131-6844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    akap1; fa08b04; wu:fa08b04
    Summary
    Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be active in membrane and mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and segmental plate. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See akap1b in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (30838271..30857350, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (30957536..30976609, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487763 Neighboring gene uncharacterized LOC137487764 Neighboring gene neurofibromin 1a Neighboring gene uncharacterized LOC137487765 Neighboring gene ecotropic viral integration site 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. Burkhalter MD, et al. J Clin Invest, 2019 May 16. PMID 31094706, Free PMC Article
    2. Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. Zhang J, et al. FASEB J, 2023 May. PMID 37086087
    3. Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Zhou S, et al. Fish Shellfish Immunol, 2016 Feb. PMID 26767746
    4. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC162884

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    A kinase (PRKA) anchor protein 1b
    Names
    A kinase (PRKA) anchor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098179.2 → NP_001091649.2  A kinase (PRKA) anchor protein 1b

      Status: VALIDATED

      Source sequence(s)
      BX000438
      UniProtKB/TrEMBL
      A0A8M6Z0N0, F1RBY1, F6NHG9
      Related
      ENSDARP00000115383.1, ENSDART00000138988.3
      Conserved Domains (3) summary
      smart00333
      Location:694 → 751
      TUDOR; Tudor domain
      cd00105
      Location:548 → 608
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:641 → 765
      TUDOR; Tudor domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      30838271..30857350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017350962.3 → XP_017206451.1  A kinase (PRKA) anchor protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z0N0, F1RBY1, F6NHG9
      Related
      ENSDARP00000099189.2, ENSDART00000112511.2
      Conserved Domains (3) summary
      smart00333
      Location:694 → 751
      TUDOR; Tudor domain
      cd00105
      Location:548 → 608
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:641 → 765
      TUDOR; Tudor domain
    Nucleotide Protein Strain
    Heading Accession and Version

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