hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd3b2provided by ZNC
Official Full Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030828-2
See related: Ensembl:ENSDARG00000019747 AllianceGenome:ZFIN:ZDB-GENE-030828-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb723; hsd3b1; zgc:122972
Summary: Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity. Acts upstream of or within embryonic morphogenesis and steroid biosynthetic process. Is expressed in brain; gonad; head kidney; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (1272526..1276400)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (1251700..1255349)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish hsd3b2(Dre 20) evolved independently of hsd3b1(Dre 9) with a morphogenetic function during early embryogenesis.
Title: Two Zebrafish hsd3b Genes Are Distinct in Function, Expression, and Evolution.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Names: 3 beta hsd; hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1

NP_997962.1

EC 1.1.1.145

EC 5.3.3.1

XP_068071491.1

EC 1.1.1.145

EC 5.3.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212797.1 → NP_997962.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

See identical proteins and their annotated locations for NP_997962.1

Status: PROVISIONAL

Source sequence(s)

AY279108

UniProtKB/TrEMBL

Q7ZZC3

Related

ENSDARP00000025516.5, ENSDART00000008115.7

Conserved Domains (2) summary

pfam01073
Location:9 → 290

3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family

cl21454
Location:7 → 359

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins