epcam epithelial cell adhesion molecule [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: epcamprovided by ZNC
Official Full Name: epithelial cell adhesion moleculeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2209
See related: Ensembl:ENSDARG00000040534 AllianceGenome:ZFIN:ZDB-GENE-040426-2209
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb6; tacstd; zgc:77119; wu:fj17g02; zgc:110304
Summary: Acts upstream of or within several processes, including embryonic morphogenesis; liver development; and posterior lateral line neuromast primordium migration. Located in basolateral plasma membrane and perinuclear region of cytoplasm. Is expressed in several structures, including digestive system; integument; pectoral fin bud; pronephros; and sensory system. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy; corneal dystrophy; gelatinous drop-like corneal dystrophy; and hereditary nonpolyposis colorectal cancer type 8. Orthologous to several human genes including EPCAM (epithelial cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (8840870..8843363)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (8508847..8511340)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene ontology analysis revealed that EpCAM controls various developmental programs, including uretric bud development, morphogenesis of branching epithelium, regulation of cell differentiation and cilium morphogenesis.
Title: EpCAM controls morphogenetic programs during zebrafish pronephros development.
EpCAM acts as a partner of E-cadherin to control adhesiveness and integrity as well as plasticity and morphogenesis within simple epithelia
Title: The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development.
Heterogeneously expressed in migrating cells of zebrafish lateral line
Title: Control of cell migration in the zebrafish lateral line: implication of the gene "tumour-associated calcium signal transducer," tacstd.

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General gene information

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Markers

fj17g02.x1 (e-PCR)
- UniSTS:198670

fb11f01.x1 (e-PCR)
- UniSTS:202842

AI384934 (e-PCR)
- UniSTS:206707

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otolith formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: epithelial cell adhesion molecule

Names: pan-epithelial glycoprotein; tumor-associated calcium signal transducer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.