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    her8a hairy-related 8a [ Danio rerio (zebrafish) ]

    Gene ID: 323656, updated on 9-Dec-2024

    Summary

    Official Symbol
    her8aprovided by ZNC
    Official Full Name
    hairy-related 8aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2376
    See related
    Ensembl:ENSDARG00000016363 AllianceGenome:ZFIN:ZDB-GENE-030131-2376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    her8b; her-8a; her-8b; zgc:85712; wu:fb75f05; wu:fc06c04
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within glial cell differentiation; negative regulation of neurogenesis; and neuron differentiation. Is active in chromatin. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; neural tube; and posterior neural keel. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See her8a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (26429941..26436482, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (26160554..26165379, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene si:dkey-3k24.8 Neighboring gene transmembrane 4 L six family member 21b Neighboring gene metallo-beta-lactamase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    hairy-related 8a
    Names
    hairy-related 8b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199624.3NP_955918.3  hairy-related 8a

      Status: VALIDATED

      Source sequence(s)
      CR848737, EH587922
      UniProtKB/TrEMBL
      A0A8M1PE83, F1QI81, F1R6H0
      Related
      ENSDARP00000111735.3, ENSDART00000123395.4
      Conserved Domains (2) summary
      cd00083
      Location:1775
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:95133
      Hairy_orange; Hairy Orange

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      26429941..26436482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172256.5XP_005172313.1  hairy-related 8a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BJI1
      Conserved Domains (2) summary
      cd00083
      Location:1775
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:91129
      Hairy_orange; Hairy Orange

    RNA

    1. XR_011016139.1 RNA Sequence