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    atp1b2a ATPase Na+/K+ transporting subunit beta 2a [ Danio rerio (zebrafish) ]

    Gene ID: 64269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atp1b2aprovided by ZNC
    Official Full Name
    ATPase Na+/K+ transporting subunit beta 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001127-2
    See related
    Ensembl:ENSDARG00000099203 AllianceGenome:ZFIN:ZDB-GENE-001127-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb711; atp1b2; zgc:86580; wu:fc09e11
    Summary
    Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to act upstream of or within potassium ion transport and sodium ion transport. Predicted to be located in membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in nervous system; neural rod; neural tube; and pancreatic bud. Orthologous to human ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See atp1b2a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (44732818..44762193)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (45020817..45050137)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 2 Neighboring gene kinesin-like protein KIF1C Neighboring gene monoacylglycerol O-acyltransferase 3a Neighboring gene si:ch73-269m23.4 Neighboring gene glycolipid transfer protein domain containing 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Two Na,K-ATPase beta 2 subunit isoforms are differentially expressed within the central nervous system and sensory organs during zebrafish embryogenesis. Rajarao JR, et al. Dev Dyn, 2002 Mar. PMID 11836789
    2. The regulation of transcriptome responses in zebrafish embryo exposure to triadimefon. Hsu LS, et al. Environ Toxicol, 2017 Jan. PMID 26790661
    3. Na(+) K(+) ATPase isoform switching in zebrafish during transition to dilute freshwater habitats. Esbaugh AJ, et al. Proc Biol Sci, 2019 May 29. PMID 31113326, Free PMC Article
    4. Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Castro LF, et al. Proc Biol Sci, 2014 Jan 22. PMID 24307675, Free PMC Article
    5. Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish. Hu M, et al. Chin Med, 2021 Nov 14. PMID 34775978, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC86580, MGC113970

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-2a
    Names
    ATPase, Na+/K+ beta 2 polypeptide
    ATPase, Na+/K+ transporting, beta 2 polypeptide
    ATPase, Na+/K+ transporting, beta 2a polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131669.3 → NP_571744.1  sodium/potassium-transporting ATPase subunit beta-2a

      See identical proteins and their annotated locations for NP_571744.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078647
      UniProtKB/TrEMBL
      A0A0R4IT77, Q6AZA3, Q9DGL2
      Related
      ENSDARP00000139476.1, ENSDART00000160044.2
      Conserved Domains (1) summary
      pfam00287
      Location:8 → 278
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      44732818..44762193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469844.2 → XP_021325519.1  sodium/potassium-transporting ATPase subunit beta-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PKU7
      Related
      ENSDARP00000138154.1, ENSDART00000166421.2
      Conserved Domains (1) summary
      pfam00287
      Location:7 → 287
      Na_K-ATPase; Sodium / potassium ATPase beta chain
    Nucleotide Protein Strain
    Heading Accession and Version

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