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    grk6 G protein-coupled receptor kinase 6 [ Danio rerio (zebrafish) ]

    Gene ID: 561288, updated on 14-Nov-2024

    Summary

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    Official Symbol
    grk6provided by ZNC
    Official Full Name
    G protein-coupled receptor kinase 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101006-5
    See related
    Ensembl:ENSDARG00000032157 AllianceGenome:ZFIN:ZDB-GENE-101006-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ATP binding activity and G protein-coupled receptor kinase activity. Predicted to act upstream of or within protein phosphorylation and signal transduction. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See grk6 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (36623446..36739299)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (36938226..37054140)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 10 Neighboring gene uncharacterized LOC137488870 Neighboring gene NOP16 nucleolar protein homolog (yeast) Neighboring gene proline rich 7, synaptic Neighboring gene drebrin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, et al. EMBO Rep, 2016 May. PMID 27113758, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 6
    XP_689783.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      36623446..36739299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_684691.9 → XP_689783.2  G protein-coupled receptor kinase 6

      UniProtKB/TrEMBL
      A0A8N7UUW2, E7F3T7
      Related
      ENSDARP00000022046.8, ENSDART00000027459.10
      Conserved Domains (3) summary
      cd08751
      Location:35 → 179
      RGS_GRK6; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 6 (GRK6)
      smart00220
      Location:186 → 445
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185 → 469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    Nucleotide Protein Strain
    Heading Accession and Version

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