rngtt RNA guanylyltransferase and 5'-phosphatase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rngttprovided by ZNC
Official Full Name: RNA guanylyltransferase and 5'-phosphataseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2087
See related: Ensembl:ENSDARG00000032261 AllianceGenome:ZFIN:ZDB-GENE-040426-2087
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:76886
Summary: Predicted to enable inorganic triphosphate phosphatase activity and mRNA guanylyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to act upstream of or within mRNA processing and protein dephosphorylation. Predicted to be located in nucleus. Orthologous to human RNGTT (RNA guanylyltransferase and 5'-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (943879..1120056, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (923053..1099230, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish.
Title: Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inorganic triphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 5'-triphosphate monophosphatase activity	IEA Inferred from Electronic Annotation more info
enables mRNA guanylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA guanylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mRNA guanylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within 7-methylguanosine mRNA capping	IEA Inferred from Electronic Annotation more info
involved_in 7-methylguanosine mRNA capping	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA-capping enzyme

Names: RNA guanylyltransferase and 5-phosphatase

NP_998032.1

EC 2.7.7.50

EC 3.6.1.74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212867.1 → NP_998032.1 mRNA-capping enzyme

See identical proteins and their annotated locations for NP_998032.1

Status: PROVISIONAL

Source sequence(s)

BC066685

UniProtKB/Swiss-Prot

Q6NY98

Related

ENSDARP00000040679.6, ENSDART00000040680.7

Conserved Domains (3) summary

cd07895
Location:252 → 465

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

pfam03919
Location:469 → 562

mRNA_cap_C; mRNA capping enzyme, C-terminal domain

cl21483
Location:37 → 143

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...