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    sgce sarcoglycan, epsilon [ Danio rerio (zebrafish) ]

    Gene ID: 368230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sgceprovided by ZNC
    Official Full Name
    sarcoglycan, epsilonprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030724-1
    See related
    Ensembl:ENSDARG00000012138 AllianceGenome:ZFIN:ZDB-GENE-030724-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    scge; zgc:92318
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in several cellular components, including Golgi apparatus; dendrite; and sarcolemma. Predicted to be part of sarcoglycan complex. Is expressed in central nervous system; retina; retinal ganglion cell layer; and retinal inner nuclear layer. Human ortholog(s) of this gene implicated in myoclonic dystonia 11. Orthologous to human SGCE (sarcoglycan epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sgce in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (41031265..41069577, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (41451542..41482486, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488548 Neighboring gene collagen, type I, alpha 2 Neighboring gene CAS1 domain containing 1 Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene ankyrin repeat and SOCS box containing 4 Neighboring gene pyruvate dehydrogenase kinase, isozyme 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sarcoglycans of the zebrafish: orthology and localization to the sarcolemma and myosepta of muscle. Chambers SP, et al. Biochem Biophys Res Commun, 2003 Apr 4. PMID 12659844
    2. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. Rodius S, et al. BMC Genomics, 2014 Oct 3. PMID 25280539, Free PMC Article
    3. Zebrafish orthologs of human muscular dystrophy genes. Steffen LS, et al. BMC Genomics, 2007 Mar 20. PMID 17374169, Free PMC Article
    4. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923
    5. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sarcoglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epsilon-sarcoglycan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002594.1 → NP_001002594.1  epsilon-sarcoglycan precursor

      See identical proteins and their annotated locations for NP_001002594.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076003
      UniProtKB/TrEMBL
      A0A8M1N0X7, Q6DHH1
      Related
      ENSDARP00000099762.2, ENSDART00000111982.4
      Conserved Domains (1) summary
      pfam05510
      Location:10 → 396
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      41031265..41069577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159717.5 → XP_005159774.1  epsilon-sarcoglycan isoform X4

      UniProtKB/TrEMBL
      A0A8M2B6H2
      Conserved Domains (1) summary
      pfam05510
      Location:10 → 396
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    2. XM_017352192.3 → XP_017207681.2  epsilon-sarcoglycan isoform X5

      UniProtKB/TrEMBL
      A0A8M6YTU0
      Conserved Domains (1) summary
      pfam05510
      Location:42 → 414
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    3. XM_017352190.3 → XP_017207679.2  epsilon-sarcoglycan isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z2W7
      Conserved Domains (1) summary
      pfam05510
      Location:42 → 414
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    4. XM_021468003.2 → XP_021323678.1  epsilon-sarcoglycan isoform X3

      UniProtKB/TrEMBL
      A0A8M9PAU2
      Conserved Domains (1) summary
      pfam05510
      Location:42 → 423
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    5. XM_021468002.2 → XP_021323677.1  epsilon-sarcoglycan isoform X1

      UniProtKB/TrEMBL
      A0A8M9P1Q4
      Conserved Domains (1) summary
      pfam05510
      Location:42 → 423
      Sarcoglycan_2; Sarcoglycan alpha/epsilon
    Nucleotide Protein
    Heading Accession and Version

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