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    coro2aa coronin 2Aa [ Danio rerio (zebrafish) ]

    Gene ID: 323538, updated on 2-Nov-2024

    Summary

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    Official Symbol
    coro2aaprovided by ZNC
    Official Full Name
    coronin 2Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2258
    See related
    Ensembl:ENSDARG00000005210 AllianceGenome:ZFIN:ZDB-GENE-030131-2258
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    coro2a; zgc:73379; wu:fc02b08
    Summary
    Predicted to enable actin filament binding activity. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; ectoderm; endoderm; neural plate; and presumptive ectoderm. Orthologous to human CORO2A (coronin 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See coro2aa in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26605228..26654311)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (25911277..25960603)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495210 Neighboring gene uncharacterized LOC137494821 Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member B Neighboring gene hemogen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish. Peters MJ, et al. Biol Open, 2018 Aug 28. PMID 30097520, Free PMC Article
    2. Evolutionary and functional diversity of coronin proteins. Xavier CP, et al. Subcell Biochem, 2008. PMID 18925374
    3. Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. Sanchez NE, et al. G3 (Bethesda), 2017 Oct 5. PMID 28855284, Free PMC Article
    4. Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. Pinto RA, et al. BMC Dev Biol, 2018 Jun 19. PMID 29914374, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coronin-2A
    Names
    coronin, actin binding protein, 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199643.2 → NP_955937.1  coronin-2A

      See identical proteins and their annotated locations for NP_955937.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060941
      UniProtKB/TrEMBL
      Q6P935
      Related
      ENSDARP00000137370.2, ENSDART00000158193.2
      Conserved Domains (5) summary
      PTZ00421
      Location:10 → 521
      PTZ00421; coronin; Provisional
      pfam08953
      Location:8 → 65
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:350 → 392
      WD40_4; Type of WD40 repeat
      sd00039
      Location:41 → 80
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 316
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      26605228..26654311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159876.5 → XP_005159933.1  coronin-2A isoform X2

      UniProtKB/TrEMBL
      A0A8M2B6N4, F1QR96
      Related
      ENSDARP00000014182.8, ENSDART00000011645.11
      Conserved Domains (5) summary
      PTZ00421
      Location:15 → 526
      PTZ00421; coronin; Provisional
      pfam08953
      Location:13 → 70
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:355 → 397
      WD40_4; Type of WD40 repeat
      sd00039
      Location:46 → 85
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:83 → 321
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_005159877.5 → XP_005159934.1  coronin-2A isoform X1

      UniProtKB/TrEMBL
      A0A0R4IRX7, A0A8M2B6I8
      Related
      ENSDARP00000144803.1, ENSDART00000182040.1
      Conserved Domains (5) summary
      PTZ00421
      Location:10 → 521
      PTZ00421; coronin; Provisional
      pfam08953
      Location:8 → 65
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:350 → 392
      WD40_4; Type of WD40 repeat
      sd00039
      Location:41 → 80
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 316
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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