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    cp ceruloplasmin [ Danio rerio (zebrafish) ]

    Gene ID: 84702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpprovided by ZNC
    Official Full Name
    ceruloplasminprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010522-1
    See related
    Ensembl:ENSDARG00000010312 AllianceGenome:ZFIN:ZDB-GENE-010522-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi23f10
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in iron ion transport. Predicted to act upstream of or within monoatomic ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including blood plasma; digestive system; liver and biliary system; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (38173974..38199757)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (38220827..38246610)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene transmembrane 4 L six family member 4 Neighboring gene transmembrane 4 L six family member 18 Neighboring gene HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene si:ch211-284e20.8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Imaging zebrafish neural circuitry from whole brain to synapse. Leung LC, et al. Front Neural Circuits, 2013. PMID 23630470, Free PMC Article
    2. Characterization of the ceruloplasmin gene and its potential role as an indirect marker for selection to Aeromonas hydrophila resistance in rohu, Labeo rohita. Sahoo PK, et al. Fish Shellfish Immunol, 2013 May. PMID 23481214
    3. Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish. Wang Z, et al. Biochem Biophys Res Commun, 2018 Oct 28. PMID 30262142
    4. Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders. Fish RJ, et al. Int J Mol Sci, 2021 Jan 11. PMID 33440782, Free PMC Article
    5. Intrahepatic biliary anomalies in a patient with Mowat-Wilson syndrome uncover a role for the zinc finger homeobox gene zfhx1b in vertebrate biliary development. Cui S, et al. J Pediatr Gastroenterol Nutr, 2011 Mar. PMID 21336163

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ceruloplasmin
    Names
    cer
    NP_571877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131802.1 → NP_571877.1  ceruloplasmin precursor

      See identical proteins and their annotated locations for NP_571877.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048037
      UniProtKB/TrEMBL
      Q7ZU12
      Related
      ENSDARP00000015293.8, ENSDART00000010537.10
      Conserved Domains (6) summary
      cd04222
      Location:23 → 205
      CuRO_1_ceruloplasmin; The first cupredoxin domain of Ceruloplasmin
      cd04225
      Location:745 → 915
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11012
      Location:927 → 1071
      CuRO_6_ceruloplasmin; The sixth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:217 → 357
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:588 → 731
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:371 → 585
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      38173974..38199757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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