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    efhd2 EF-hand domain family, member D2 [ Danio rerio (zebrafish) ]

    Gene ID: 571114, updated on 2-Nov-2024

    Summary

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    Official Symbol
    efhd2provided by ZNC
    Official Full Name
    EF-hand domain family, member D2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060531-152
    See related
    Ensembl:ENSDARG00000055759 AllianceGenome:ZFIN:ZDB-GENE-060531-152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb80e07; si:dkey-72l14.9
    Summary
    Predicted to enable calcium ion binding activity. Orthologous to human EFHD2 (EF-hand domain family member D2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See efhd2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (25818622..25846188, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (25799483..25827049, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1S subunit, b Neighboring gene TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor Neighboring gene opsin 7, group member c Neighboring gene transmembrane protein 115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Is your "gene of interest" interesting? Kiefer JC. Dev Dyn, 2007 Oct. PMID 17849447
    2. Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions. Dütting S, et al. Cell Commun Signal, 2011 Jan 18. PMID 21244694, Free PMC Article
    3. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand domain-containing protein D2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326493.1 → NP_001313422.1  EF-hand domain-containing protein D2

      Status: VALIDATED

      Source sequence(s)
      BX784025, CK026993, EH591880
      UniProtKB/TrEMBL
      A2RUX3, Q1LVD7
      Related
      ENSDARP00000108177.2, ENSDART00000128829.3
      Conserved Domains (2) summary
      cd00051
      Location:89 → 147
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:90 → 147
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      25818622..25846188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001045211.2: Suppressed sequence

      Description
      NM_001045211.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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